methyl (3-aminopropyl)carbamate | 898822-53-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (3-aminopropyl)carbamate
• 英文别名: methyl N-(3-aminopropyl)carbamate
• CAS: 898822-53-2
• 化学式: C₅H₁₂N₂O₂
• 分子量: 132.162
• InChiKey: GDYWGBIREFAREI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl (3-aminopropyl)carbamate 、 8-(4-(trifluoromethyl)cyclohex-1-en-1-yl)quinoline-3-carboxylic acid 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以15.26 %的产率得到methyl (2-(8-(4-(trifluoromethyl)cyclohex-1-en-1-yl)quinoline-3-carboxamido)ethyl)carbamate
  参考文献：
  名称：

  [EN] TEAD INHIBITORS AND METHODS OF USE
  [FR] INHIBITEURS DE TEAD ET PROCEDES D'UTILISATION

  摘要：

  The present disclosure provides, in part, compounds of formula (I), wherein the variables are as defined herein, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat physiological disorders, such as proliferative disorders, mediated by TEA domain transcription factors.

  公开号：

  WO2023183437A1
• 作为产物：
  描述：

  tert-butyl methyl propane-1,3-diyldicarbamate 在 盐酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 以95.03 %的产率得到methyl (3-aminopropyl)carbamate
  参考文献：
  名称：

  [EN] TEAD INHIBITORS AND METHODS OF USE
  [FR] INHIBITEURS DE TEAD ET PROCEDES D'UTILISATION

  摘要：

  The present disclosure provides, in part, compounds of formula (I), wherein the variables are as defined herein, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat physiological disorders, such as proliferative disorders, mediated by TEA domain transcription factors.

  公开号：

  WO2023183437A1

文献信息

• Reactions of Dimethyl Carbonate with Aliphatic Amines Under High Pressure
  作者：Davor Margetić、Irena Zrinski Antonac、Zoran Glasovac、Mirjana Eckert-Maksić、Ljiljana Maksimović

  DOI：10.1080/00397911.2010.501644

  日期：2011.8

  Abstract A facile synthesis of methyl carbamates from primary amines and dimethyl carbonate has been achieved at room temperature using high pressure. High-pressure synthesis of methyl carbamates described herein provides access to the target molecules in an efficient and environmentally friendly way without solvent or catalyst. Better conversion and selectivity than previously published procedures

  摘要 已在室温下使用高压从伯胺和碳酸二甲酯轻松合成氨基甲酸甲酯。本文描述的氨基甲酸甲酯的高压合成以高效且环境友好的方式提供了在没有溶剂或催化剂的情况下获得目标分子的途径。获得了比以前公开的程序更好的转化率和选择性。
• Direct Esterification of Alkylcarbamic Acids with Alcohols over CeO₂ Catalyst
  作者：Shogen Mihara、Mizuho Yabushita、Yoshinao Nakagawa、Keiichi Tomishige

  DOI：10.1002/cssc.202301436

  日期：2024.2.22

  Transformation of CO2-captured amines: Direct esterification of benzylcarbamic acid, which is easily produced via CO2 absorption by benzylamine, was demonstrated with methanol over CeO2 catalyst. The target product was synthesized in 64 % yield in the optimal conditions. CeO2 catalyst was reusable and widely applicable to various substrates.

  CO 2 -捕获的胺的转化：在CeO 2催化剂上用甲醇证明了苄基氨基甲酸的直接酯化，这很容易通过苄胺吸收CO 2产生。在最佳条件下合成了目标产物，收率64%。 CeO 2催化剂可重复使用，广泛适用于各种基材。