(4aR,6R,7R,8R,8aR)-7,8-dihydroxy-6-methoxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-2-carboxylic acid | 92569-54-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: (4aR,6R,7R,8R,8aR)-7,8-dihydroxy-6-methoxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxine-2-carboxylic acid
• CAS: 92569-54-5
• 化学式: C₁₀H₁₆O₈
• 分子量: 264.23
• InChiKey: ZDZVLEQWFATHTF-VGMWHSNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• THERAPEUTIC AND DIAGNOSTIC AGENTS FOR AMYLOIDOSIS
  申请人：ROYAL POSTGRADUATE MEDICAL SCHOOL

  公开号：EP0714405A1

  公开（公告）日：1996-06-05
• PHARMACEUTICAL COMPOSITIONS CONTAINING THE LONG PENTRAXIN PTX3
  申请人：SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1034185B1

  公开（公告）日：2005-05-18
• THERAPEUTIC AGENT FOR DEPLETION OF AN UNWANTED PROTEIN POPULATION FROM PLASMA
  申请人：Pentraxin Therapeutics Limited

  公开号：EP1418905B1

  公开（公告）日：2007-05-02
• Therapeutic agent for depletion of an unwanted protein population from plasma
  申请人：Pentraxin Therapeutics Limited

  公开号：EP1820501B1

  公开（公告）日：2011-09-14
• THERAPEUTIC AGENT
  申请人：Pepys Mark

  公开号：US20060014665A1

  公开（公告）日：2006-01-19

  The invention relates to an agent for the depletion of unwanted proteins from plasma comprising a plurality of ligands covalently co-linked to produce a complex with a plurality of proteins wherein at least two of the ligands are capable of being bound by ligand binding sites on the proteins and wherein the non-protein access agent excludes certain D-proline derivatives.