3,3-dimethyl-2-methylene-1-octadecyl-6-phenylindoline | 180003-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3,3-dimethyl-2-methylene-1-octadecyl-6-phenylindoline
• 英文别名: 3,3-Dimethyl-2-methylidene-1-octadecyl-6-phenylindole
• CAS: 180003-62-7
• 化学式: C₃₅H₅₃N
• 分子量: 487.813
• InChiKey: PFNWQFAFPMJDTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.9
• 重原子数：
  36
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,3-dimethyl-2-methylene-1-octadecyl-6-phenylindoline 在 硫酸 作用下， 以 吡啶 为溶剂， 生成 1,1'-dioctadecyl-6,6'-di(4-sulfophenyl)-3,3,3',3'-tetramethylindocarbocyanine
  参考文献：
  名称：

  Lipophilic sulfophenylcarbocyanine dyes: Synthesis of a new class of fluorescent cell membrane probes

  摘要：

  Two lipophilic sulfophenylcarbocyanine dyes, 3 and 4, were synthesized as a new class of fluorescent cell membrane probes. Compared with other commonly used membrane probes, the new dyes have improved fluorescent quantum yield, retention in cell membranes and are easier to use in staining cells. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00263-6
• 作为产物：
  描述：

  在 碳酸氢钠 作用下， 以 水 为溶剂， 生成 3,3-dimethyl-2-methylene-1-octadecyl-6-phenylindoline
  参考文献：
  名称：

  Lipophilic sulfophenylcarbocyanine dyes: Synthesis of a new class of fluorescent cell membrane probes

  摘要：

  Two lipophilic sulfophenylcarbocyanine dyes, 3 and 4, were synthesized as a new class of fluorescent cell membrane probes. Compared with other commonly used membrane probes, the new dyes have improved fluorescent quantum yield, retention in cell membranes and are easier to use in staining cells. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00263-6

文献信息

• Lipophilic cyanine dyes with enchanced aqueous solubilty
  申请人：Molecular Probes, Inc.

  公开号：US06004536A1

  公开（公告）日：1999-12-21

  The present invention relates to a family of cyanine dyes possessing lipophilic alkyl chains and either one or more reactive functional groups, bromo or chloro, or phenyl, sulfophenyl or polysulfophenyl substituents or combinations thereof. The dyes of the invention are useful for staining membranes in cells or isolated from cells, and are well-retained therein. Additionally, the reactive dyes of the invention are useful for preparing dye-conjugates, thereby conferring the membrane staining ability of the subject dye onto the resulting dye-conjugate.

  本发明涉及一类具有亲脂性烷基链和溴或氯或苯基、磺基苯基或多磺基苯基取代基或其组合的靛菁染料家族。本发明的染料适用于染色细胞中的膜或从细胞中分离出来的膜，并且在其中保持良好。此外，本发明的活性染料适用于制备染料共轭物，从而将所述染料的膜染色能力赋予所得染料共轭物。
• US6004536A
  申请人：——

  公开号：US6004536A

  公开（公告）日：1999-12-21