(E)-1-phenyl-2-pentyl-oct-2-en-1-ol | 125642-14-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-1-phenyl-2-pentyl-oct-2-en-1-ol
• 英文别名: (E)-2-pentyl-1-phenyl-2-octen-1-ol；(E)-2-pentyl-1-phenyloct-2-en-1-ol
• CAS: 125642-14-0
• 化学式: C₁₉H₃₀O
• 分子量: 274.447
• InChiKey: SFFSDTZWFNBFNT-SAPNQHFASA-N

物化性质

• 沸点：
  388.4±11.0 °C(Predicted)
• 密度：
  0.928±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-十二炔 、 苯甲醛 生成 (E)-1-phenyl-2-pentyl-oct-2-en-1-ol
  参考文献：
  名称：

  On the mechanism of titanocenedichloride-catalysed hydromagnesiation of alkynes with alkyl Grignard reagents

  摘要：

  烯烃与烷基格氏试剂的钛二氯化物催化氢化镁化反应机理得到阐明，并揭示了反应的立体化学受控于从钛到镁的过渡金属化步骤。

  DOI：

  10.1039/c39950000659

文献信息

• Formal hydrochromination of alkynes under nickel catalysis. Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols
  作者：Kazuhiko Takai、Shuji Sakamoto、Takahiko Isshiki、Tatsuya Kokumai

  DOI：10.1016/j.tet.2006.04.105

  日期：2006.8

  Formal hydrochromation of an alkyne leading to a 1-substituted ethenylchromium reagent is accomplished by addition of the alkyne and water to a mixture of low-valent chromium(II), a catalytic amount of nickel(II), and triphenylphosphine in DMF.

  通过将炔烃和水添加到DMF中低价铬（II），催化量的镍（II）和三苯基膦的混合物中来完成炔烃的正式加氢染色以生成1取代的乙烯基铬试剂。
• Regioselective Reductive Coupling of Alkynes and Aldehydes Leading to Allylic Alcohols
  作者：Kazuhiko Takai、Shuji Sakamoto、Takahiko Isshiki

  DOI：10.1021/ol0272996

  日期：2003.3.1

  Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl(2) and a catalytic amount of NiCl(2) and triphenylphosphine in the presence of water in DMF at 25 degrees C gives a 1,2-disubstituted allylic alcohol regioselectively.

  在25°C的DMF中在水的存在下用CrCl（2）和催化量的NiCl（2）和三苯膦处理末端炔烃和醛的混合物，在区域选择性地生成1,2-二取代的烯丙基醇。
• Halogen-Magnesium Exchange via Trialkylmagnesates for the Preparation of Aryl- and Alkenylmagnesium Reagents
  作者：Kazuya Kitagawa、Atsushi Inoue、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1002/1521-3773(20000717)39:14<2481::aid-anie2481>3.0.co;2-j

  日期：2000.7.17
• Selective Halogen−Magnesium Exchange Reaction via Organomagnesium Ate Complex
  作者：Atsushi Inoue、Kazuya Kitagawa、Hiroshi Shinokubo、Koichiro Oshima

  DOI：10.1021/jo015597v

  日期：2001.6.1

  Halogen-magnesium exchange of various aryl halides is achieved with a magnesium ate complex at low temperatures; Tributylmagnesate ((Bu3MgLi)-Bu-n) induces facile iodine-magnesium exchange at -78 degreesC. Dibutylisopropylmagnesate ((PrBu2MgLi)-Pr-i-Bu-n) is more reactive than (Bu3MgLi)-Bu-n, and this reagent accomplishes selective bromine-magnesium exchange at -78 degreesC. This procedure is utilized for the preparation of various polyfunctionalized arylmagnesium species. The exchange of alkenyl halides using this method proceeds with retention of configuration of the double bond.
• Tantalum-alkyne complexes as synthetic intermediates. Stereoselective preparation of trisubstituted allylic alcohols from acetylenes and aldehydes
  作者：Kazuhiko Takai、Y. Kataoka、K. Utimoto

  DOI：10.1021/jo00293a008

  日期：1990.3