6-bromo-3-[(6-bromo-1H-indol-3-yl)-(4-chlorophenyl)methyl]-1H-indole | 1195738-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-bromo-3-[(6-bromo-1H-indol-3-yl)-(4-chlorophenyl)methyl]-1H-indole
• CAS: 1195738-13-6
• 化学式: C₂₃H₁₅Br₂ClN₂
• 分子量: 514.647
• InChiKey: RVHBRWVKTKJWSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  31.6
• 氢给体数：
  2
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  6-溴吲哚 、 4-氯苯甲醛 在 cerium(III) chloride heptahydrate 作用下， 以 甘油 为溶剂， 反应 10.0h， 以77%的产率得到6-bromo-3-[(6-bromo-1H-indol-3-yl)-(4-chlorophenyl)methyl]-1H-indole
  参考文献：
  名称：

  Glycerin and CeCl3·7H2O: a new and efficient recyclable medium for the synthesis of bis(indolyl)methanes

  摘要：

  Glycerin and CeCl3 center dot 7H(2)O were successfully used in recyclable catalytic system for the synthesis of several bis(indolyl)methanes in good to excellent yields through the reaction of indoles with aldehydes. The method is applicable to aliphatic and aromatic aldehydes, and the mixture of glycerin and CeCl3-7H(2)O can be reused up to five times without special treatment and with comparable yields. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.062

文献信息

• Glycerin and CeCl3·7H2O: a new and efficient recyclable medium for the synthesis of bis(indolyl)methanes
  作者：Claudio C. Silveira、Samuel R. Mendes、Francieli M. Líbero、Eder J. Lenardão、Gelson Perin

  DOI：10.1016/j.tetlet.2009.08.062

  日期：2009.11

  Glycerin and CeCl3 center dot 7H(2)O were successfully used in recyclable catalytic system for the synthesis of several bis(indolyl)methanes in good to excellent yields through the reaction of indoles with aldehydes. The method is applicable to aliphatic and aromatic aldehydes, and the mixture of glycerin and CeCl3-7H(2)O can be reused up to five times without special treatment and with comparable yields. (C) 2009 Elsevier Ltd. All rights reserved.