4-mesyloxy-6-methyl-2-pyrone | 149013-45-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-mesyloxy-6-methyl-2-pyrone
• 英文别名: (2-Methyl-6-oxopyran-4-yl) methanesulfonate
• CAS: 149013-45-6
• 化学式: C₇H₈O₅S
• 分子量: 204.204
• InChiKey: ZKTKUYSUYITQKE-UHFFFAOYSA-N

物化性质

• 熔点：
  84-85 °C
• 沸点：
  354.8±42.0 °C(predicted)
• 密度：
  1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-mesyloxy-6-methyl-2-pyrone 在 三氯异氰尿酸 作用下， 以 乙酸乙酯 为溶剂， 以31%的产率得到3-chloro-4-mesyloxy-6-methyl-2-pyrone
  参考文献：
  名称：

  区域选择性氯化和4-烷氧基香豆素，4-烷氧基-2-吡喃酮及相关杂环的铃木-宫浦交叉偶联

  摘要：

  具有生物重要性的4-烷氧基香豆素的氯化反应是通过使用三氯异氰尿酸（一种替代N-氯琥珀酰亚胺的方法）实现的。Suzuki-Miyaura将氯代香豆素与各种硼酸的交叉偶联提供了高达99％的收率的产品。该协议已成功应用于相关的2-pyrone，2-pyridone和2-quinolone衍生物。

  DOI：

  10.1002/ejoc.201700837
• 作为产物：
  描述：

  4-羟基-6-甲基-2-吡喃酮 、 甲基磺酰氯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 2.17h， 以81%的产率得到4-mesyloxy-6-methyl-2-pyrone
  参考文献：
  名称：

  区域选择性氯化和4-烷氧基香豆素，4-烷氧基-2-吡喃酮及相关杂环的铃木-宫浦交叉偶联

  摘要：

  具有生物重要性的4-烷氧基香豆素的氯化反应是通过使用三氯异氰尿酸（一种替代N-氯琥珀酰亚胺的方法）实现的。Suzuki-Miyaura将氯代香豆素与各种硼酸的交叉偶联提供了高达99％的收率的产品。该协议已成功应用于相关的2-pyrone，2-pyridone和2-quinolone衍生物。

  DOI：

  10.1002/ejoc.201700837

文献信息

• A New Approach to Fused 1,2-Diazepines by Cyclization of Enhydrazines with a- and b-Keto Esters
  作者：Tetsuo Yamasaki、Kaoru Nishida、Yoshinari Okamoto、Tadashi Okawara、Mitsuru Furukawa

  DOI：10.3987/com-97-s(n)19

  日期：——

  The cyclization of 6-(1,2-diethoxycarbonylethylidene)hydrazino-1,3-dimethyluracil (3) and 6-(1,2-diethoxycarbonylethylidene)hydrazino-3-methyl-2-methylthiopyrimidin-4(3H)-one (8) in the presence of polyphosphoric acid (PPA) provided 2,5-dihydropyrimido[4,5-c]-1,2-diazepine-5,6,8(1H,7H,9H)-trione (4) and 4,5-dihydropyrimido[4,5-c]-1,2-diazepine-5,6(1H,7H)-dione (9), respectively. 4-Hydrazino-5-methyl-2-pyrone (27) and 5,5-dimethyl-3-hydrazinnocyclohexen-1-one (31) readily reacted with ethyl benzoylacetate (28) to give 4,5-dihydropyrano[4,3-c]-1,2-diazepine-5 (30) and 3-phenyl-1,8,8-trimethyl-4,5,6,7,8,9-hexahydro-1,2-benzodiazepine-5,6(1H)-dione (33), respectively.
• Near Infrared Ray Activation Type Positive Resin Composition
  申请人：Imai Genji

  公开号：US20070259279A1

  公开（公告）日：2007-11-08

  A near infrared ray activation type positive resist composition comprising (A) a vinyl-based polymer having a monomer unit having an alkali-soluble group blocked by an ether having an alkenyl group next to an ether oxygen, (B) a photothermal converting substance generating heat by a light in the near infrared region, (C) a thermal acid generator generating an acid by heat, can provide a near infrared ray activation type positive resist composition which can be subjected to an exposure treatment in a complete bright room such as under a white light and the like, gives desired sensitivity and resolution, and of which baking treatment conditions can be relaxed or a baking treatment can be omitted, and a pattern formation method using the same.
• Positive resist composition for recording medium master, and method of producing recording medium master and method of producing stamper using the same
  申请人：Imai Genji

  公开号：US20090045552A1

  公开（公告）日：2009-02-19

  Provided are a positive resist composition for recording medium master showing excellent plating resistance and adhesion to a base plate such as glass or the like characterized by containing a vinyl polymer which has a monomer unit having an alkali-soluble group blocked by an alkyl vinyl ether, and a method of producing a recording medium master or stamper using this positive resist composition.
• US7544461B2
  申请人：——

  公开号：US7544461B2

  公开（公告）日：2009-06-09
• Regioselective Chlorination and Suzuki-Miyaura Cross-Coupling of 4-Alkoxycoumarins, 4-Alkoxy-2-pyrones, and Related Heterocycles
  作者：Aisling M. Prendergast、Gerard P. McGlacken

  DOI：10.1002/ejoc.201700837

  日期：2017.9.1

  The chlorination of biologically important 4-alkoxycoumarins was achieved by using trichloroisocyanuric acid, a favorable alternative to N-chlorosuccinimide. The Suzuki–Miyaura cross-coupling of chlorinated coumarins with various boronic acids afforded the products in up to 99 % yield. This protocol was successfully applied to related 2-pyrone, 2-pyridone, and 2-quinolone derivatives.

  具有生物重要性的4-烷氧基香豆素的氯化反应是通过使用三氯异氰尿酸（一种替代N-氯琥珀酰亚胺的方法）实现的。Suzuki-Miyaura将氯代香豆素与各种硼酸的交叉偶联提供了高达99％的收率的产品。该协议已成功应用于相关的2-pyrone，2-pyridone和2-quinolone衍生物。