2-allyloxy-3-ethoxy-benzaldehyde | 1099675-89-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-allyloxy-3-ethoxy-benzaldehyde
• 英文别名: 3-Ethoxy-2-prop-2-enoxybenzaldehyde
• CAS: 1099675-89-4
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: OSJMPCFNMHYSPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-allyloxy-3-ethoxy-benzaldehyde 在 3-mesityl-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以68%的产率得到8-ethoxy-3-methyl-chroman-4-one
  参考文献：
  名称：

  N-Heterocyclic Carbene-Catalyzed Hydroacylation of Unactivated Double Bonds

  摘要：

  An intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated double bonds is reported. Systematic variation of the catalyst structure revealed an N-mesitylthiazolylidene annulated with a seven-membered ring to be especially reactive. This NHC enables a unique C-C bond-forming reaction to afford substituted chroman-4-ones in moderate to excellent yields, even ones containing all-carbon quaternary centers.

  DOI：

  10.1021/ja906361g
• 作为产物：
  描述：

  3-乙氧基水杨醛 、 3-溴丙烯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以95%的产率得到2-allyloxy-3-ethoxy-benzaldehyde
  参考文献：
  名称：

  可见光诱导的自由基级联酰甲基化/2-(烯丙氧基)芳醛与α-溴酮的环化：获得含有环状1,5-二羰基的色满-4-酮骨架

  摘要：

  描述了一种新颖的光催化方案，通过2-(烯丙氧基)芳醛与 α-溴酮的自由基级联酰甲基化/环化，以中等至良好的产率有效且高效地合成含有色满 4-酮骨架的环状 1,5-二酮。该反应具有广泛的底物范围、良好的官能团耐受性以及无金属和氧化剂的条件。涉及酰甲基自由基引发的级联环化。

  DOI：

  10.1039/d3ob01101a

文献信息

• Stereoselective Synthesis of Isoxazolinobenzoxepanes via Intramolecular Nitrile Oxide Cycloaddition
  作者：P. Perumal、K. Ramachandiran、K. Karthikeyan、T. Nandhakumar、D. Muralidharan

  DOI：10.1055/s-0030-1260201

  日期：2011.10

  Concise routes to the synthesis of indole-tethered nitrile oxides have been developed, and their intramolecular nitrile oxide cycloadditions were studied. Heterocyclic scaffolds involving isoxazolinobenzoxepane frameworks have been achieved via intramolecular nitrile oxide cycloaddition of 3-[1-(2-allyloxyphenyl)-2-nitroethyl]-1H-indole derivatives using (Boc)2O and DMAP. This protocol affords products

  已经开发了合成吲哚链状丁腈氧化物的简便方法，并研究了其分子内丁腈氧化物的环加成反应。涉及isoxazolinobenzoxepane框架杂环支架已经通过3-分子内氧化腈环加成获得[1-（2-烯丙氧基苯基）-2-硝基乙基〕-1- ħ使用（BOC） -吲哚衍生物2 O和DMAP。该协议为产品提供了出色的反选择性。 分子内一氧化氮环加成反应-迈克尔加成反应-异恶唑啉代苯并氧杂庚烷-反式选择性
• Direct synthesis of 4-hydroxycoumarins and 4-hydroxy-6-methyl-2-pyrone containing chroman-4-ones <i>via</i> a silver catalyzed radical cascade cyclization reaction
  作者：Suraj Sharma、Bipul Sarma、Gakul Baishya

  DOI：10.1039/d1nj03437e

  日期：——

  cyclization reaction of 2-(allyloxy)arylaldehydes to synthesize two new libraries of chroman-4-ones by using 4-hydroxycoumarins and 4-hydroxy-6-methyl-2-pyrone as radical precursors. AgNO3/K2S2O8 acts as an efficient oxidizing system and smoothly drives the reaction producing the 4-hydroxycoumarins and 4-hydroxy-6-methyl-2-pyrone containing chroman-4-ones in moderate to good yields. The protocol also makes

  我们首次报道了一种新型银催化的 2-(烯丙氧基)芳基醛的自由基级联环化反应，通过使用 4-羟基香豆素和 4-羟基-6-甲基-2-吡喃酮合成了两个新的色满-4-酮库作为激进的先驱。AgNO 3 /K 2 S 2 O 8作为一种有效的氧化系统，可以平稳地推动反应，以中等至良好的收率产生 4-羟基香豆素和 4-羟基-6-甲基-2-吡喃酮，其中含有 chroman-4-ones。该协议还使用 2-(but-3-en-1-yloxy) 苯甲醛作为自由基受体来制造不同的化学选择性产品。我们通过使用 2,2,6,6-四甲基哌啶-1-氧基、丁基化羟基甲苯和二苯基乙烯进行各种自由基捕获实验，证实了自由基的参与。
• SLOW-RELEASE FORMULATION CONTAINING GEL COMPOSITION FOR USE ON PESTS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2805615A1

  公开（公告）日：2014-11-26

  Provided is a sustained release preparation comprising an insect pest-targeting gel composition, the preparation being free from leakage or reaction of a volatile substance and being capable of releasing the volatile substance at a constant rate. More specifically, provided is a sustained release preparation comprising a polymer tube and an insect pest-targeting gel composition in the polymer tube, the composition comprising one or more volatile substances and an oil gelling agent, wherein the volatile substances are comprised in an amount of from 70.0 to 99.0% by weight by the insect pest-targeting composition and are released outside of the polymer tube through the polymer tube.

  本发明提供了一种包含害虫靶向凝胶组合物的缓释制剂，该制剂中的挥发性物质不会泄漏或发生反应，并且能够以恒定的速率释放挥发性物质。更具体地说，本发明提供了一种持续释放制剂，包括聚合物管和聚合物管中的害虫靶向凝胶组合物，该组合物包括一种或多种挥发性物质和油胶凝剂，其中挥发性物质的含量为害虫靶向组合物重量的 70.0% 至 99.0%，并通过聚合物管释放到聚合物管外。
• Insect pest-targeting gel composition and sustained release preparation comprising that
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US10244750B2

  公开（公告）日：2019-04-02

  Provided are an insect pest-targeting gel composition causing neither leakage nor reaction of a volatile substance and capable of releasing the volatile substance at a constant rate; and a sustained release preparation including the insect pest-targeting gel composition. More specifically, provided is an insect pest-targeting gel composition including one or more volatile substances and an oil gelling agent, wherein the volatile substance is included in an amount of from 70.0 to 99.0% by weight by the insect pest-targeting gel composition.

  本发明提供了一种害虫靶向凝胶组合物，该组合物不会导致挥发性物质泄漏或反应，并能以恒定速率释放挥发性物质；还提供了一种包含该害虫靶向凝胶组合物的缓释制剂。更具体地说，提供了一种包含一种或多种挥发性物质和油胶凝剂的害虫靶向凝胶组合物，其中挥发性物质的含量为害虫靶向凝胶组合物重量的 70.0% 至 99.0%。
• Highly stereo and chemoselective synthesis of tetra and pentacyclic frameworks using Solid-State Melt Reaction (SSMR)
  作者：Manickam Bakthadoss、Govindan Sivakumar

  DOI：10.1016/j.tetlet.2014.01.126

  日期：2014.3

  Benzopyran fused tetra and pentacyclic frameworks have been synthesized by the domino Knoevenagel hetero Diels-Alder (DKHDA) reaction using various 1,3-diones with O-allylated salicylaldehydes and O-propargylated salicylaldehydes in a solvent and catalyst free condition via Solid-State Melt Reaction (SSMR). The reaction requires only a single step operation thus providing potentially bioactive polycyclic heterocycles in high yields. (C) 2014 Elsevier Ltd. All rights reserved.