4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxylic acid | 1094219-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxylic acid
• 英文别名: 4-oxo-1,2,3,5-tetrahydro-1,5-benzodiazepine-7-carboxylic acid
• CAS: 1094219-66-5
• 化学式: C₁₀H₁₀N₂O₃
• mdl: MFCD11180938
• 分子量: 206.2
• InChiKey: RVEFJTNHWHRSDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamides
  申请人：Bayer Aktiengesellschaft

  公开号：US11161825B2

  公开（公告）日：2021-11-02

  The present invention covers 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamide compounds of general formula (I): in which R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, R5 and X are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer, as a sole agent or in combination with other active ingredients.

  本发明涉及通式（I）的 4-氧代-2,3,4,5-四氢-1H-1,5-苯并二氮杂卓-7-甲酰胺化合物：其中 R1、R2a、R2b、R2c、R3a、R3b、R4a、R4b、R5 和 X 如本文所定义；制备所述化合物的方法；用于制备所述化合物的中间体化合物；包含所述化合物的药物组合物和组合物；以及使用所述化合物制造用于治疗或预防疾病（尤其是癌症）的药物组合物，作为单独制剂或与其他活性成分组合使用。
• 4-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE-7-CARBOXAMIDES
  申请人：Bayer Aktiengesellschaft

  公开号：US20200199083A1

  公开（公告）日：2020-06-25

  The present invention covers 4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamide compounds of general formula (I): in which R 1 , R 2a , R 2b , R 2c , R 3a , R 3b , R 4a , R 4b , R 5 and X are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer, as a sole agent or in combination with other active ingredients.