tert-butyl N-methyl-N-[[2-[4-[2-(5-trimethylsilylpenta-2,4-diynoyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]carbamate | 848642-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: tert-butyl N-methyl-N-[[2-[4-[2-(5-trimethylsilylpenta-2,4-diynoyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]carbamate
• CAS: 848642-02-4
• 化学式: C₂₉H₂₉NO₃SSi
• 分子量: 499.706
• InChiKey: QJXDSKUOSGXXEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.59
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl N-methyl-N-[[2-[4-[2-(5-trimethylsilylpenta-2,4-diynoyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]carbamate 以 苯 为溶剂， 以82%的产率得到Tert-butyl 2-methyl-9-oxo-11-(2-trimethylsilylethynyl)-7-thia-20-azapentacyclo[10.8.0.03,10.04,8.013,18]icosa-1(12),2,4(8),5,10,13,15,17-octaene-20-carboxylate
  参考文献：
  名称：

  Synthesis of indenothiophenone derivatives by cycloaromatization of non-conjugated thienyl tetraynes

  摘要：

  Non-conjugated thienyl tetrayne derivatives 1-3 are prepared as novel building block for the construction of indenothiophenone derivatives. Oxidation of 1-3, followed by cycloaromatization of the corresponding ketone derivatives 13-15 proceeds smoothly to afford indenothiophenone derivatives 16-21 in good yields. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.005
• 作为产物：
  描述：

  3-溴噻吩-2-甲醛 在 三丁基氯化锡 、 甲基锂 、 戴斯-马丁氧化剂 、 二异丙胺 、 lithium bromide 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 tert-butyl N-methyl-N-[[2-[4-[2-(5-trimethylsilylpenta-2,4-diynoyl)thiophen-3-yl]buta-1,3-diynyl]phenyl]methyl]carbamate
  参考文献：
  名称：

  Synthesis of indenothiophenone derivatives by cycloaromatization of non-conjugated thienyl tetraynes

  摘要：

  Non-conjugated thienyl tetrayne derivatives 1-3 are prepared as novel building block for the construction of indenothiophenone derivatives. Oxidation of 1-3, followed by cycloaromatization of the corresponding ketone derivatives 13-15 proceeds smoothly to afford indenothiophenone derivatives 16-21 in good yields. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.01.005