N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide | 93493-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide
• 英文别名: 2,2-dimethyl-N-(2-chloro-4-formyl-5-pyridinyl)propanamide；N-(6-chloro-4-formylpyridin-3-yl)pivalamide；N-(6-chloro-4-formylpyridin-3-yl)-2,2-dimethylpropanamide
• CAS: 93493-66-4
• 化学式: C₁₁H₁₃ClN₂O₂
• 分子量: 240.689
• InChiKey: NFPXRZAYLJWZRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide 在 盐酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 4.5h， 生成 6-氯-1,7-萘啶-2(1H)-酮
  参考文献：
  名称：

  A general approach to the synthesis of 1,6-, 1,7-, and 1,8-naphthyridines

  摘要：

  DOI：

  10.1021/jo00302a049
• 作为产物：
  描述：

  三甲基乙酰氯 在 叔丁基锂 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide
  参考文献：
  名称：

  A general approach to the synthesis of 1,6-, 1,7-, and 1,8-naphthyridines

  摘要：

  DOI：

  10.1021/jo00302a049

文献信息

• [EN] AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE<br/>[FR] COMPOSÉS AMINO HÉTÉROARYLES COMME MODULATEURS DE LA BÊTA-SECRÉTASE ET PROCÉDÉS D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2011063233A1

  公开（公告）日：2011-05-26

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B1, B2, B3, L, R1, R4, R5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

  本发明涵盖了一类新化合物，用于调节β-分泌酶酶活性，治疗由β-分泌酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。在一个实施例中，这些化合物具有一般的化学式I，其中化合物I的环A、B1、B2、B3、L、R1、R4、R5和m在此定义。该发明还包括将这些化合物用于制备药物组合物，用于治疗与β-分泌酶蛋白活性相关的疾病和症状，包括例如阿尔茨海默病（AD）、认知缺陷、认知损害、精神分裂症和其他与大脑斑块形成和/或沉积有关和/或由此引起的中枢神经系统疾病。该发明还包括化合物I的进一步实施例、中间体和用于制备化合物I的过程。
• Naphthyridinyloxy(or thio)phenoxy propanoic acids, derivatives thereof
  申请人：The Dow Chemical Company

  公开号：US04472193A1

  公开（公告）日：1984-09-18

  Novel 2-naphthyridinyloxy(or thio)phenoxy propanoic acid compounds of the formula ##STR1## wherein ##STR2## represents a 6 membered nitrogen containing an aromatic ring which forms a 1,5-, 1,6-, 1,7- or 1,8-naphthyridinyl moiety with the adjoining pyridine ring, said naphthyridinyl moiety optionally substituted at the 6 position of the naphthyridinyl moiety with a chloro, bromo, iodo, CF.sub.3, or fluoro atom; A represents O or S; and agriculturally acceptable salts, esters, ethers, and amides thereof, are useful as fungicides and herbicides, particularly effective against grassy weeds.

  2-萘啶氧基(或硫代)苯氧基丙酸类化合物的化学式如下：其中表示含有6个成员的氮芳环，与相邻的吡啶环形成1,5-、1,6-、1,7-或1,8-萘啶基团，所述的萘啶基团在6位可能被氯、溴、碘、三氟甲基或氟原子取代；A代表O或S；其农业上可接受的盐、酯、醚和酰胺，可用作杀菌剂和除草剂，特别对草本杂草有效。
• Certain naphthyridine diether compounds and their herbicidal use
  申请人：The Dow Chemical Company

  公开号：US04536208A1

  公开（公告）日：1985-08-20

  Novel 2-naphthyridinyloxy(or thio)phenoxy propanoic acid compounds of the formula ##STR1## wherein ##STR2## represents a 6 membered nitrogen containing an aromatic ring which forms a 1,5-, 1,6-, 1,7- or 1,8-naphthyridinyl moiety with the adjoining pyridine ring, said naphthyridinyl moiety optionally substituted at the 6 position of the naphthyridinyl moiety with a chloro, bromo, iodo, CF.sub.3, or fluoro atom; A represents 0 or S; and agriculturally acceptable salts, esters, ethers, and amides thereof, are useful as fungicides and herbicides, particularly effective against grassy weeds.

  2-萘啶氧（或硫）苯氧丙酸化合物的化学式为##STR1##其中##STR2##代表一含有氮的6元芳环，该环与相邻的吡啶环形成1,5-、1,6-、1,7-或1,8-萘啶基团，所述萘啶基团在6位上可选地被氯、溴、碘、CF.sub.3或氟原子取代; A代表0或S; 以及其农业上可接受的盐、酯、醚和酰胺，可用作杀菌剂和除草剂，特别对草本杂草有效。
• Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use
  申请人：Cheng Yuan

  公开号：US20120329830A1

  公开（公告）日：2012-12-27

  The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B 1 , B 2 , B 3 , L, R 1 , R 4 , R 5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

  本发明涉及一类新的化合物，可用于调节β-分泌酶酶活性和治疗β-分泌酶介导的疾病，包括阿尔茨海默病（AD）和相关疾病。在一种实施例中，所述化合物具有一般式I，其中环A、B1、B2、B3、L、R1、R4、R5和m在本文中有定义。本发明还包括使用这些化合物制备药物组合物，用于治疗与β-分泌酶蛋白活性相关的疾病和症状，例如阿尔茨海默病（AD）、认知缺陷、认知障碍、精神分裂症以及与大脑斑块形成和/或沉积相关和/或由其引起的其他中枢神经系统疾病。本发明还包括式I的进一步实施例、中间体和用于制备式I化合物的过程。
• TURNER, JAMES A., J. ORG. CHEM., 55,(1990) N5, C. 4744-4750
  作者：TURNER, JAMES A.

  DOI：——

  日期：——