4-ethoxy-3-methyl-6-phenyl-2H-pyran-2-one | 1197325-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-ethoxy-3-methyl-6-phenyl-2H-pyran-2-one
• 英文别名: 4-Ethoxy-3-methyl-6-phenylpyran-2-one；4-ethoxy-3-methyl-6-phenylpyran-2-one
• CAS: 1197325-14-6
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: FDOUMEBRPQCBSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-ethoxy-2-methyl-5-phenylpent-2-en-4-ynoic acid 在 溶剂黄146 、 silver carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 9.0h， 以64%的产率得到4-ethoxy-3-methyl-6-phenyl-2H-pyran-2-one
  参考文献：
  名称：

  Stereoselective Synthesis of (E)-2-En-4-ynoic Acids with Ynolates: Catalytic Conversion to Tetronic Acids and 2-Pyrones

  摘要：

  A highly torquoselective olefination of alkynoates to provide functionalized tetrasubstituted olefins, (E)-2-en-4-ynoic acids, is described. Addition of Bronsted acids dramatically switched the mode of the Ag(l)-catalyzed cyclization of the resulting enyne carboxylic acids to give either tetronic acids or 2-pyrones.

  DOI：

  10.1021/ol902086t

文献信息

• NOVEL PHARMACEUTICAL COMPOUND HAVING A CHOLESTEROL ACYLTRANSFERASE ISOZYME 2 (ACAT2) -INHIBITING ACTIVITY
  申请人：School Juridical Person Kitasato Institute

  公开号：EP3162805B1

  公开（公告）日：2019-08-07
• Stereoselective Synthesis of (<i>E</i>)-2-En-4-ynoic Acids with Ynolates: Catalytic Conversion to Tetronic Acids and 2-Pyrones
  作者：Takashi Yoshikawa、Mitsuru Shindo

  DOI：10.1021/ol902086t

  日期：2009.12.3

  A highly torquoselective olefination of alkynoates to provide functionalized tetrasubstituted olefins, (E)-2-en-4-ynoic acids, is described. Addition of Bronsted acids dramatically switched the mode of the Ag(l)-catalyzed cyclization of the resulting enyne carboxylic acids to give either tetronic acids or 2-pyrones.