(Z)-4-Brom-3-ethoxycrotonsaeure-ethylester | 65840-69-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-4-Brom-3-ethoxycrotonsaeure-ethylester
• 英文别名: ethyl 4-bromo-3-ethoxy-2-butenoate；ethyl (Z)-4-bromo-3-ethoxybut-2-enoate
• CAS: 65840-69-9
• 化学式: C₈H₁₃BrO₃
• 分子量: 237.093
• InChiKey: FYYMWILFRUUBCX-ALCCZGGFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-苯基-5-噁唑酮 、 (Z)-4-Brom-3-ethoxycrotonsaeure-ethylester 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以39%的产率得到(Z),(Z)-4,4-Bis<2-ethoxy-3-(ethoxycarbonyl)allyl>-2-phenyl-2-oxazolin-5-on
  参考文献：
  名称：

  Lohmar, Rainald; Steglich, Wolfgang, Chemische Berichte, 1980, vol. 113, # 12, p. 3706 - 3715

  摘要：

  DOI：
• 作为产物：
  描述：

  3-乙氧基-顺式-巴豆酸乙酯 、 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 以90%的产率得到
  参考文献：
  名称：

  KOCHHAR, K. S.;PINNICK, H. W., J. ORG. CHEM., 1984, 49, N 17, 3222-3224

  摘要：

  DOI：

文献信息

• Synthesis of Allylic and Propargylic Trifluoromethyl Thioethers by Copper(I)-Catalyzed Trifluoromethylthiolation of Allylic Bromides and Propargylic Chlorides
  作者：Mingguang Rong、Dongzhe Li、Ronglu Huang、Yangjie Huang、Xiaoyan Han、Zhiqiang Weng

  DOI：10.1002/ejoc.201402480

  日期：2014.8

  copper(I)-catalyzed trifluoromethylthiolation of allylic bromides by using elemental sulfur and CF3SiMe3. This rate of this transformation was significantly accelerated in the presence of 18-crown-6, and the reaction afforded the desired products in moderate to excellent yields with high stereo- and regioselectivity. This method can tolerate a number of functional groups and provides facile access to a variety

  报道了一种使用元素硫和 CF3SiMe3 对烯丙基溴进行铜 (I) 催化的三氟甲基硫醇化反应的有效方法。在 18-crown-6 的存在下，这种转化速度显着加快，反应以中等至极好的收率提供了所需的产物，具有高立体选择性和区域选择性。这种方法可以容忍许多官能团，并且可以轻松获得各种烯丙基三氟甲基硫醚。还研究了铜 (I) 催化的炔丙基氯化物的三氟甲硫基化反应。提出了一种涉及烯丙基铜 (III) 中间体的合理机制。
• Synthesis of propargylic and allylic trifluoromethyl selenoethers by copper-mediated trifluoromethylselenolation of propargylic chlorides and allylic bromides
  作者：Mingguang Rong、Ronglu Huang、Yi You、Zhiqiang Weng

  DOI：10.1016/j.tet.2014.09.091

  日期：2014.11

  The copper-mediated trifluoromethylselenolation of propargylic chlorides and allylic bromides is described. This approach provides a wide range of propargylic and allylic trifluoromethyl selenoethers in moderate to good yields. These results open the way to synthesis strategies for various trifluoromethylselenolated compounds.

  描述了炔丙基氯化物和烯丙基溴的铜介导的三氟甲基硒化。该方法以中等至良好的产率提供了各种炔丙基和烯丙基三氟甲基硒醚。这些结果为各种三氟甲基硒化化合物的合成策略开辟了道路。
• PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS
  申请人：NAZARÉ Marc

  公开号：US20110039829A1

  公开（公告）日：2011-02-17

  The present invention relates to compounds of the formula I, wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable, e.g., for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

  本发明涉及公式I的化合物，其中R1; R2; Z; A; B; D; Q; J; V; G和M具有所述声明中指示的含义。公式I的化合物是有价值的药理活性化合物。它们表现出强烈的抗血小板聚集作用，从而具有抗血栓作用，并适用于治疗和预防心血管疾病，如血栓栓塞性疾病或再狭窄。它们是血小板ADP受体P2Y12的可逆拮抗剂，并且通常适用于存在不良激活血小板ADP受体P2Y12的情况或者治愈或预防需要抑制血小板ADP受体P2Y12的情况。本发明还涉及公式I的化合物的制备过程，它们的使用，特别是作为药物中的活性成分，以及包含它们的制药制剂。
• Novel benzopyranylpyrrolinone derivatives
  申请人：RECHERCHE SYNTEX FRANCE SA

  公开号：EP0377966A2

  公开（公告）日：1990-07-18

  Compounds of the formula wherein: R₁ is cyano or nitro; R₂ and R₃ are independently hydrogen or lower alkyl; and R₄ is alkyl; alkenyl; optionally substituted phenyl or phenyl lower alkyl; -(CH₂)mOR₂ or -(CH₂)mN(R₂)₂; wherein m is an integer of 1-5 and R₂ is as defined above; or a pharmaceutically acceptable ester or acid addition salt thereof; are smooth muscle relaxants, particularly useful in the treatment of hypertension.

  式中的化合物 其中 R₁ 是氰基或硝基； R₂ 和 R₃ 独立地为氢或低级烷基；以及 R₄ 是烷基；烯基；任选取代的苯基或苯基低级烷基；-(CH₂)mOR₂ 或-(CH₂)mN(R₂)₂；其中 m 是 1-5 的整数，R₂ 如上文所定义； 或其药学上可接受的酯或酸加成盐； 是平滑肌松弛剂，尤其适用于治疗高血压。
• A facile KF/Al2O3 mediated, selective alkylation of benzodiazepin-2,5-diones
  作者：Benjamin E Blass、Thomas M Burt、Song Liu、David E Portlock、Erin M Swing

  DOI：10.1016/s0040-4039(00)00115-5

  日期：2000.3

  We have developed a new, versatile method for the selective alkylation of benzodiazepin-2,5-diones using KF on Al2O3 The use of a reagent on a solid support makes this process suitable for the preparation of combinatorial libraries. (C) 2000 Elsevier Science Ltd. All rights reserved.