cyclohexyl 4-formylphenylcarbamate | 1324000-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cyclohexyl 4-formylphenylcarbamate
• 英文别名: cyclohexyl N-(4-formylphenyl)carbamate
• CAS: 1324000-33-0
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: MLKXDXKYWZFFJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对醛基苯甲酸 、 环己醇 在 叠氮基三甲基硅烷 、 1-丙基磷酸酐 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以94%的产率得到cyclohexyl 4-formylphenylcarbamate
  参考文献：
  名称：

  丙基膦酸酐（T3P®）介导的羧酸一锅重排成氨基甲酸酯

  摘要：

  的羧酸的简单的一锅转变成氨基甲酸酯通过丙基膦酸酐（T3P实现®与azidotrimethylsilane组合），并通过Curtius重排的醇。除了多样化的伯醇至叔醇外，该反应还耐受各种芳族，杂环和脂肪族羧酸，这些羧酸经过重排后具有极高的收率。 丙基膦酸酐-Curtius重排-氨基甲酸酯-肽偶联剂-叠氮基三甲基硅烷

  DOI：

  10.1055/s-0030-1259964

文献信息

• [EN] CYCLOHEXYL CARBAMATE COMPOUNDS AS ACTIVE ANTI-CELLULITE INGREDIENTS<br/>[FR] COMPOSÉS CARBAMATE DE CYCLOHÉXYLE SERVANT DE PRINCIPES ACTIFS ANTI-CELLULITE
  申请人：SYMRISE GMBH & CO KG

  公开号：WO2010097479A2

  公开（公告）日：2010-09-02

  The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as anti-cellulite actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising such compounds of formula (I), which are preferably suitable for the prophylaxis (prevention) and cosmetic treatment (combating) of cellulite in human beings, corresponding methods and novel compounds of formula (I) wherein A denotes (II), wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.
• [EN] CYCLOHEXYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES<br/>[FR] COMPOSÉS DE CARBAMATE DE CYCLOHEXYLE UTILES EN TANT QU'ACTIFS ÉCLAIRCISSANTS POUR LA PEAU ET/OU LES CHEVEUX/POILS
  申请人：SYMRISE GMBH & CO KG

  公开号：WO2010122178A2

  公开（公告）日：2010-10-28

  The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2- C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.