1-(3-(5-Fluoro-1h-Indol-2-Yl)phenyl)piperidin-4-Yl)(2-(4-Isopropyl-Piperazin1-Yl)ethyl)-Carbamate | 1883351-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(3-(5-Fluoro-1h-Indol-2-Yl)phenyl)piperidin-4-Yl)(2-(4-Isopropyl-Piperazin1-Yl)ethyl)-Carbamate
• 英文别名: 1-[3-(5-fluoro-1H-indol-2-yl)phenyl]-N-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]piperidin-4-amine
• CAS: 1883351-01-6
• 化学式: C₂₈H₃₈FN₅
• 分子量: 463.6
• InChiKey: LZHXZCVDLATFAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Phenyl indole allosteric inhibitors of p97 ATPase
  申请人：University of Pittsburgh—Of the Commonwealth System of Higher Education

  公开号：US10633370B2

  公开（公告）日：2020-04-28

  The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

  本发明涉及抑制 p97 的方法以及用于此类方法的化合物和组合物。可以用本发明的化合物和组合物治疗的疾病和病症包括但不限于易受 p97 抑制治疗的癌症和神经退行性疾病。
• Phenyl indole allosteric inhibitors of P97 ATPase
  申请人：University of Pittsburgh—Of the Commonwealth System of Higher Education

  公开号：US11247985B2

  公开（公告）日：2022-02-15

  The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

  本发明涉及抑制 p97 的方法以及用于此类方法的化合物和组合物。可以用本发明的化合物和组合物治疗的疾病和病症包括但不限于易受 p97 抑制治疗的癌症和神经退行性疾病。
• PHENYL INDOLE ALLOSTERIC INHIBITORS OF P97 ATPASE
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20200157082A1

  公开（公告）日：2020-05-21

  The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.