9-(diethylamino)-5-<(2-octyldecyl)imino>-5H-benzophenoxazine | 132234-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 9-(diethylamino)-5-<(2-octyldecyl)imino>-5H-benzophenoxazine
• CAS: 132234-44-7
• 化学式: C₃₈H₅₅N₃O
• 分子量: 569.874
• InChiKey: ICVAQSQRYBGWQH-ICKFRXAFSA-N

物化性质

• 沸点：
  650.3±55.0 °C(Predicted)
• 密度：
  1.03±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.95
• 重原子数：
  42.0
• 可旋转键数：
  19.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  41.63
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-辛基癸酸 在 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 甲苯 为溶剂， 反应 9.0h， 生成 9-(diethylamino)-5-<(2-octyldecyl)imino>-5H-benzophenoxazine
  参考文献：
  名称：

  Immobilization of components in polymer membrane-based calcium-selective bulk optodes

  摘要：

  A large variety of optical sensors based on thin plasticized PVC membranes have been realized in the past. The organic membrane (bulk optode) contains the analyte recognition molecule such as a selective neutral ionophore, a H+-selective chromolonophore, and lipophilic anionic sites. In order to improve the lifetime of analytically relevant sensing layers, their active components are covalently immobilized to the polymeric matrix. Different Ca2+-selective bulk optodes with mobile or fixed chromolonophores and anionic sites are characterized and discussed with respect to sensor behavior such as dynamic range, repeatability, response time, selectivity, and lifetime. In general, the response time increases upon immobilization of components owing to limited diffusion within the membrane phase, whereas the lifetime is enhanced drastically by a hindered loss of membrane components Into the sample.

  DOI：

  10.1021/ac00042a004

文献信息

• Microsphere optical ion sensors based on doped silica gel templates
  申请人：Bakker Eric

  公开号：US20060240560A1

  公开（公告）日：2006-10-26

  A sensor for determining the concentration of a target ion in a liquid sample having a particulate silica doped with: an ionophore capable of binding the target ion; and an indicator capable of producing a detectable signal in response to binding by the ionophore of the target ion. The detectable signal is related to the target ion concentration in the liquid sample.

  一种用于测定液体样品中目标离子浓度的传感器，其中包含掺杂有颗粒状的二氧化硅，其中包含：能够结合目标离子的离子载体；以及能够在离子载体结合目标离子的响应下产生可检测信号的指示剂。可检测信号与液体样品中目标离子的浓度相关。
• Systems and methods for detecting an optical change indicating the presence of an analyte
  申请人：Case Western Reserve University

  公开号：US10393665B2

  公开（公告）日：2019-08-27

  One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. The analyte sensor device can also include a selectively-permeable membrane encapsulating the optode layer to form a stable membrane that that minimizes fouling of the analyte sensor device. The analyte sensor device can also include a plurality of microparticles that suppress a background physical interference on a detection of the optical change of the optode layer.

  本公开的一个方面涉及一种分析物传感器装置。分析物传感器装置可以包括一个光电极层，在分析物存在的情况下，光电极层会发生光学变化。分析物传感器装置还可以包括封装光电极层的选择性渗透膜，以形成稳定的膜，最大限度地减少分析物传感器装置的堵塞。分析物传感器装置还可以包括多个微颗粒，以抑制背景物理干扰对光极层光学变化的检测。
• Composite material for the detection of chemical species
  申请人：INSTITUT NATIONAL D'OPTIQUE

  公开号：US11193915B2

  公开（公告）日：2021-12-07

  A composite material for sensing a chemical species in a medium is provided. The composite material includes a polymer having a glass transition temperature, a porosity promoter dispersed in the polymer in an amount such that the chemical species is transportable from the medium into the composite material at a temperature below the glass transition temperature, and a chemical indicator dispersed in the composite material, the chemical indicator providing an optical response varying with a concentration of the chemical species in the composite material.

  提供了一种用于感知介质中化学物质的复合材料。复合材料包括具有玻璃化转变温度的聚合物、分散在聚合物中的孔隙度促进剂（其用量应能使化学物质在低于玻璃化转变温度的温度下从介质传输到复合材料中）以及分散在复合材料中的化学指示剂，化学指示剂提供随复合材料中化学物质浓度变化而变化的光学响应。
• Immunologically based strip test utilizing ionophore membranes
  申请人：——

  公开号：US20010034036A1

  公开（公告）日：2001-10-25

  A testing apparatus 10 having an absorbent matrix 12 , including a membrane 14 which contains a plurality of counter-ions 16. Chromionophore (or fluorionophore)s 18 and affinophores 22 compete to carry ions into the membrane 14 and neutralize the charge of the counterions 16. Biological recognition molecules 42 bind to a portion of the affinophores 22 and prevent them from entering the membrane 14, thereby allowing more chromionophore (or fluorionophore)s 18 to enter the membrane 14. The portion of affinophores 22 bound to the biological recognition molecules 42 is inversely proportional to the amount or concentration of analyte 40 occurring within the solution or medium 30. The result of this is that the color of the membrane-covered matrix changes in a manner related to the concentration of the analyte. One application of this apparatus is a strip test for prediction of ovulation.

  测试仪器 10 具有吸收基质 12 包括一层薄膜 14 其中包含多个反离子 16. 发色团（或荧光团）18 18 和 affinophores 22 竞争携带离子进入膜 14 并中和反离子的电荷 16. 生物识别分子 42 与部分亲和分子结合 22 并阻止它们进入膜 14, 从而使更多的发色团（或荧光团）18 18 进入膜 14. 亲和荧光团 22 与生物识别分子结合的部分 42 与分析物的量或浓度成反比。 40 的量或浓度成反比。 30. 其结果是，膜覆盖基质的颜色以与分析物浓度相关的方式发生变化。这种仪器的一种应用是预测排卵的条带测试。
• Sliver type autonomous biosensors
  申请人：——

  公开号：US20040180391A1

  公开（公告）日：2004-09-16

  In vivo or in vitro monitoring of chemical and biochemical species (e.g., pH, or glucose levels) in the interstitial fluid of patients or in a sample of a fluid to be analyzed is provided by a probe ( 10, 70, 210, 270 ). For in vivo monitoring, the probe is readily inserted by a minimally invasive method. Optical or electrochemical sensing methods are employed to detect a physical or chemical change, such as pH, color, electrical potential, electric current, or the like, which is indicative of the concentration of the species or chemical property to be detected. Visual observation by the patient may be sufficient to monitor certain biochemicals (e.g., glucose) with this approach. A CAP membrane allows high enzyme loadings, and thus enables use of microminiature probes, and/or diagnosis of low levels of the analyte(s), with sufficient signal-to-noise ratio and low background current.

  探针可在体内或体外监测患者间质或待分析液体样本中的化学和生化物质（如 pH 值或葡萄糖水平） ( 10, 70, 210, 270 ).对于体内监测，探针可通过微创方法轻松插入。采用光学或电化学传感方法来检测物理或化学变化，如 pH 值、颜色、电势、电流等，这表明要检测的物种或化学性质的浓度。使用这种方法，病人的肉眼观察就足以监测某些生化物质（如葡萄糖）。CAP 膜允许高酶负荷，因此可以使用微型探针和/或诊断低水平的分析物，同时具有足够的信噪比和低背景电流。