methyl 3-[5-[(E,6S)-6-hydroxyhept-1-enyl]furan-2-yl]propanoate | 1004519-97-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 3-[5-[(E,6S)-6-hydroxyhept-1-enyl]furan-2-yl]propanoate
• CAS: 1004519-97-4
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.337
• InChiKey: BKZDMFYYPHTPKF-PZBABLGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  、 三甲基硅烷化重氮甲烷 以 正己烷 、 丙酮 、 苯 为溶剂， 反应 0.17h， 以0.9 mg的产率得到methyl 3-[5-[(E,6S)-6-hydroxyhept-1-enyl]furan-2-yl]propanoate
  参考文献：
  名称：

  New Cytotoxic 14-Membered Macrolides from Marine-Derived Fungus Aspergillus ostianus

  摘要：

  Three new 14-membered macrolides, named aspergillides A, B, and C (1, 5, and 7), were isolated from marine-derived fungus Aspergillus ostianus strain 01F313, cultured in a medium composed of bromine-modified artificial seawater. The structures of the new compounds were determined by analyses of 1D and 2D NMR spectra. Their absolute configurations were elucidated by the modified Mosher's method and chemical conversions. The new compounds showed cytotoxic activity against mouse lymphocytic leukemia cells (L1210).

  DOI：

  10.1021/ol702598q