| 1415795-66-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1415795-66-2
• 化学式: C₁₃H₂₇N₃O₁₀S
• 分子量: 417.437
• InChiKey: KJQJLPCEGVZSTK-WELRSGGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.42
• 重原子数：
  27.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  230.38
• 氢给体数：
  11.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  α-cellobiose 、 氨基硫脲 在 sodium cyanoborohydride 作用下， 以 水 为溶剂， 反应 72.0h， 生成
  参考文献：
  名称：

  Hybrid immobilization of galactosyl lactose and cellobiose on a gold substrate to modulate biological responses

  摘要：

  Bioactive O-beta-D-galactopyranosyl-(1 -> 4)-O-beta-D-galactopyranosyl-(1 -> 4)-D-glucopyranose (4'-galactosyl lactose) was site-selectively modified at a reducing end with thiosemicarbazide (TSC). As-synthesized 4'-galactosyl lactose-TSC was immobilized on a gold substrate with cellobiose-TSC as a spacer through spontaneous self-assembly chemisorption via S-Au bonding. Quartz crystal microbalance analysis suggested the successful formation of self-assembled monolayers (SAMs) of 4'-galactosyl lactose-TSC and/or cellobiose-TSC. Galactose-binding lectin exhibited the highest affinity for hybrid SAMs with an equimolar ratio of the two oligosaccharide-TSCs, while glucose-binding lectin showed decreasing adsorption with a decrease in cellobiose-TSC ratios. Human hepatocellular carcinoma cells, which recognize galactose residues, efficiently adhered to the hybrid SAMs. Higher enzymatic deethoxylation of ethoxyresorufin via cytochrome P450 appeared on hybrid SAMs. These results suggested that clustering of the bioactive sugars was involved in the cellular responses, possibly via biological carbohydrate-protein interactions. This approach to designing carbohydrate-based scaffolds should provide a basis for the functional development of glyco-decorated biointerfaces for cell culture applications. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2012.09.088