2-[(4-Bromophenyl)sulfanyl]cyclohexan-1-one | 636602-77-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[(4-Bromophenyl)sulfanyl]cyclohexan-1-one
• 英文别名: 2-(4-bromophenyl)sulfanylcyclohexan-1-one
• CAS: 636602-77-2
• 化学式: C₁₂H₁₃BrOS
• mdl: MFCD12145519
• 分子量: 285.205
• InChiKey: SSWUYNOPUGRSFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-二溴苯基二硫化物 、 环己酮 在 potassium phosphate 作用下， 以 二甲基亚砜 为溶剂， 反应 20.0h， 以64%的产率得到2-[(4-Bromophenyl)sulfanyl]cyclohexan-1-one
  参考文献：
  名称：

  α-Organylchalcogenation of aldehydes and ketones with diorganyl dichalcogenides promoted by K3PO4

  摘要：

  A new catalytic method for direct alpha-organylchalcogenation of aldehydes and ketones has been developed. When various aldehydes and ketones were allowed to react with diorganyl dichalcogenides in the presence of K3PO4, under mild reaction conditions, the corresponding alpha-organylseleno and alpha-arylthio aldehydes and ketones were obtained in good to high yields.

  DOI：

  10.1007/s00706-014-1188-7

文献信息

• N-Chlorosuccinimide as a versatile reagent for the sulfenylation of ketones: a facile synthesis of α-ketothioethers
  作者：J.S. Yadav、B.V. Subba Reddy、Ruchi Jain、Gakul Baishya

  DOI：10.1016/j.tetlet.2008.02.136

  日期：2008.4

  The sulfenylation of ketones having alpha-hydrogens has been achieved using N-chlorosuccinimide (NCS) under mild reaction conditions to produce alpha-ketothioethers in excellent yields with high selectivity. The use of NCS makes this method quite simple, convenient and practical. (C) 2008 Published by Elsevier Ltd.
• α-Organylchalcogenation of aldehydes and ketones with diorganyl dichalcogenides promoted by K3PO4
  作者：Barahman Movassagh、Ali Yousefi

  DOI：10.1007/s00706-014-1188-7

  日期：2014.7

  A new catalytic method for direct alpha-organylchalcogenation of aldehydes and ketones has been developed. When various aldehydes and ketones were allowed to react with diorganyl dichalcogenides in the presence of K3PO4, under mild reaction conditions, the corresponding alpha-organylseleno and alpha-arylthio aldehydes and ketones were obtained in good to high yields.