4-甲基磺酰基-联苯-4-羧酸 | 728918-90-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-甲基磺酰基-联苯-4-羧酸
• 中文别名: 4'-甲基硫烷基-联苯-4-羧酸
• 英文名称: 4'-(methylsulfanyl)biphenyl-4-carboxylic acid
• 英文别名: 4'-Methylsulfanyl-biphenyl-4-carboxylic acid；4-(4-methylsulfanylphenyl)benzoic acid
• CAS: 728918-90-9
• 化学式: C₁₄H₁₂O₂S
• 分子量: 244.314
• InChiKey: BXTOMBLVPMYFNH-UHFFFAOYSA-N

物化性质

• 沸点：
  428.9±38.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  4-甲基磺酰基-联苯-4-羧酸 在 N-甲基吡咯烷酮 、 sodium thiomethoxide 、 盐酸 作用下， 反应 49.0h， 以25%的产率得到4'-mercapto-biphenyl-4-carboxylic acid
  参考文献：
  名称：

  Deep UV Photopatterning of Biphenyl Thiol Self-Assembled Monolayer and its Physical Properties

  摘要：

  Aromatic thiol such as a 4'-mercapto-biphenyl-4-carboxylic acid was synthesized, and then the self-assembled monolayer (SAM) was fabricated on a gold substrate. The pattern formation of biphenyl thiol and alkanethiol SAMs was obtained by oxidation reaction due to the irradiation of deep UV light. The resulting positive pattern image and current-voltage (I-V) characteristics of biphenyl thiol and alkanethiols were investigated through the measurements of Atomic Force Microscope (AFM) and Scanning Tunneling Microscope (STM). In addition, cytochrome c protein was immobilized onto the patterned gold substrate by self-assembly technique and electrochemical activity was studied with a cyclic voltammetry.

  DOI：

  10.1080/15421400601027981
• 作为产物：
  描述：

  4-溴茴香硫醚 、 4-羧基苯硼酸 在 四(三苯基膦)钯 potassium carbonate 作用下， 以 乙二醇二甲醚 、 水 为溶剂， 反应 18.0h， 以94%的产率得到4-甲基磺酰基-联苯-4-羧酸
  参考文献：
  名称：

  Deep UV Photopatterning of Biphenyl Thiol Self-Assembled Monolayer and its Physical Properties

  摘要：

  Aromatic thiol such as a 4'-mercapto-biphenyl-4-carboxylic acid was synthesized, and then the self-assembled monolayer (SAM) was fabricated on a gold substrate. The pattern formation of biphenyl thiol and alkanethiol SAMs was obtained by oxidation reaction due to the irradiation of deep UV light. The resulting positive pattern image and current-voltage (I-V) characteristics of biphenyl thiol and alkanethiols were investigated through the measurements of Atomic Force Microscope (AFM) and Scanning Tunneling Microscope (STM). In addition, cytochrome c protein was immobilized onto the patterned gold substrate by self-assembly technique and electrochemical activity was studied with a cyclic voltammetry.

  DOI：

  10.1080/15421400601027981

文献信息

• ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR
  申请人：Buchmann Bernd

  公开号：US20090023741A1

  公开（公告）日：2009-01-22

  The present invention relates to aryl/hetarylamide derivatives of the general formula I, process for their preparation, and the use thereof for the manufacture of pharmaceutical compositions for the treatment of disorders and indications connected with the EP 2 receptor.

  本发明涉及通式I的芳基/杂环酰胺衍生物，其制备方法，以及用于制造治疗与EP2受体相关的疾病和适应症的药物组合物的用途。
• FERROELEKTRISCHE FLÜSSIGKRISTALLINE PHASEN
  申请人：MERCK PATENT GmbH

  公开号：EP0334925A1

  公开（公告）日：1989-10-04
• [EN] ARYL/HETARYLAMIDES AS MODULATORS OF THE EP2 RECEPTOR<br/>[FR] ARYL/HÉTARYLAMIDES EN TANT QUE MODULATEURS DU RÉCEPTEUR EP2
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2008152099A2

  公开（公告）日：2008-12-18

  [EN] The present invention relates to aryl/ hetarylamide derivativ es of the general formula (I), process for their preparation, and the use thereof for the manufacture of pharmaceutical compositions for the treatment of disorders and indications connected with the EP2 receptor.
  [FR] La présente invention porte sur des dérivés d'aryle/hétarylamide de la formule générale (I), sur un procédé pour leur préparation et sur l'utilisation de ceux-ci dans la fabrication de compositions pharmaceutiques pour le traitement de troubles et d'indications associés au récepteur EP2.
• Deep UV Photopatterning of Biphenyl Thiol Self-Assembled Monolayer and its Physical Properties
  作者：Se Young Oh、Hee Jeong Kim、Hyung Seok Choi

  DOI：10.1080/15421400601027981

  日期：2007.1.22

  Aromatic thiol such as a 4'-mercapto-biphenyl-4-carboxylic acid was synthesized, and then the self-assembled monolayer (SAM) was fabricated on a gold substrate. The pattern formation of biphenyl thiol and alkanethiol SAMs was obtained by oxidation reaction due to the irradiation of deep UV light. The resulting positive pattern image and current-voltage (I-V) characteristics of biphenyl thiol and alkanethiols were investigated through the measurements of Atomic Force Microscope (AFM) and Scanning Tunneling Microscope (STM). In addition, cytochrome c protein was immobilized onto the patterned gold substrate by self-assembly technique and electrochemical activity was studied with a cyclic voltammetry.