3,4-dimethyl-2-methoxytrimethylsilyloxy benzene | 119048-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,4-dimethyl-2-methoxytrimethylsilyloxy benzene
• 英文别名: 3,4Dimethyl-2-methoxytrimethylsilyloxy benzene；(2-methoxy-3,4-dimethylphenoxy)-trimethylsilane
• CAS: 119048-10-1
• 化学式: C₁₂H₂₀O₂Si
• 分子量: 224.375
• InChiKey: LNASKYZKYOETFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.53
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲氧基-3,4-二甲基苯酚 生成 3,4-dimethyl-2-methoxytrimethylsilyloxy benzene
  参考文献：
  名称：

  ADAMS, JULIAN;GUINDON, YVAN;BELANGER, PATRICE C.;BELLEY, MICHEL L.;ROKACH+

  摘要：

  DOI：

文献信息

• 4,7-diacyloxybenzofuran derivatives
  申请人：MERCK FROSST CANADA INC.

  公开号：EP0295851A1

  公开（公告）日：1988-12-21

  4,7-Diacyloxybenzofuran derivatives of Formula I, are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents.

  公开了公式I的4,7-Diacyloxybenzofuran衍生物。这些化合物可用作哺乳动物白三烯生物合成的抑制剂。因此，这些化合物是用于治疗过敏性疾病、哮喘、心血管疾病、炎症、牛皮癣和过敏性结膜炎的有用治疗剂。这些化合物也可用作镇痛剂和细胞保护剂。
• 4,7-benzofurandione derivatives useful as inhibitors of leukotriene
  申请人：Merck Frosst Canada

  公开号：US04778805A1

  公开（公告）日：1988-10-18

  4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##

  本文介绍了公式I的4,7-苯并呋喃二酮衍生物、制药组合物和治疗方法。这些化合物可用作哺乳动物白三烯生物合成的抑制剂。因此，这些化合物是治疗过敏性疾病、哮喘、心血管疾病、炎症、银屑病和过敏性结膜炎的有用治疗剂。这些化合物也可用作镇痛剂和细胞保护剂。此外，还介绍了新的中间体，可用于制备本发明的4,7-苯并呋喃二酮。##STR1##
• 4,7-Benzofurandione derivatives
  申请人：MERCK FROSST CANADA INC.

  公开号：EP0301692A3

  公开（公告）日：1989-03-15

  4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardio­vascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention.

  本文披露了公式I的4,7-苯并呋喃二酮衍生物、制药组合物和治疗方法。这些化合物可用作哺乳动物白三烯生物合成的抑制剂。因此，这些化合物是治疗过敏性疾病、哮喘、心血管疾病、炎症、银屑病和过敏性结膜炎的有用治疗剂。这些化合物也可用作镇痛剂和细胞保护剂。本文还披露了新型中间体，可用于制备本发明的4,7-苯并呋喃二酮。
• 4,7-diacetoxy-2-(4-methoxybenzyl)-3,5,6-trimethylbenzofuran
  申请人：Merck Frosst Canada, Inc.

  公开号：US04800228A1

  公开（公告）日：1989-01-24

  4,7-Diacyloxybenzofuran derivatives of Formula I, are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. ##STR1##

  公开了式I的4,7-Diacyloxybenzofuran衍生物。这些化合物可用作哺乳动物白三烯生物合成的抑制剂。因此，这些化合物是治疗过敏症、哮喘、心血管疾病、炎症、银屑病和过敏性结膜炎的有用治疗剂。这些化合物还可用作镇痛剂和细胞保护剂。 ##STR1##
• ADAMS, JULIAN;GUINDON, YVAN;BELANGER, PATRICE C.;BELLEY, MICHEL L.;ROKACH+
  作者：ADAMS, JULIAN、GUINDON, YVAN、BELANGER, PATRICE C.、BELLEY, MICHEL L.、ROKACH+

  DOI：——

  日期：——