2-(1-hydroxy-ethyl)-pent-4-enoic acid | 73553-30-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(1-hydroxy-ethyl)-pent-4-enoic acid
• 英文别名: β-Oxy-ε-hexylen-γ-carbonsaeure；β-Oxy-α-allyl-buttersaeure；2-(1-Hydroxy-aethyl)-pent-4-ensaeure；3-Methylsaeure-hexen-(5)-ol-(2)；2-(1-Hydroxyethyl)pent-4-enoic acid
• CAS: 73553-30-7；142697-18-5
• 化学式: C₇H₁₂O₃
• mdl: MFCD19230215
• 分子量: 144.17
• InChiKey: XQIFCQQFALRWEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙酰基-4-戊酸乙酯 在 sodium amalgam 作用下， 生成 2-(1-hydroxy-ethyl)-pent-4-enoic acid
  参考文献：
  名称：

  Zeidler, Justus Liebigs Annalen der Chemie, 1877, vol. 187, p. 39

  摘要：

  DOI：

文献信息

• Recombinant microorganism expressing polyhydroxyalkanoate biosynthesis enzyme and intracellular PHA depolymerase
  申请人：——

  公开号：US20030143703A1

  公开（公告）日：2003-07-31

  The present invention provides recombinant plasmids containing a gene coding for polyhydroxyalkanoate (PHA) biosynthesis enzyme and a gene coding for intracellular PHA depolymerase, and a process for preparing (R)-hydroxycarboxylic acid employing the same. In accordance with the present invention, optically pure (R)-hydroxycarboxylic acid can be prepared by culturing E. coli transformed with a recombinant plasmid which expresses intracellular PHA depolymerase of Ralstonia eutropha and PHA biosynthesis enzyme of Alcaligenes latus to give (R)-hydroxycarboxylic acid. The process for preparing (R)-hydroxycarboxylic acid of the invention can be successfully employed in large-scale continuous process with a high productivity by carrying out PHA synthesis and degradation in a simultaneous manner, while enjoying the benefits of simple procedures for harvesting cells and disposing the cell wastes.

  本发明提供了含有编码聚羟基烷酸（PHA）生物合成酶的基因和编码细胞内 PHA 解聚酶的基因的重组质粒，以及用其制备 (R)- 羟基羧酸的工艺。根据本发明，光学纯的(R)-羟基羧酸可以通过培养 大肠杆菌 培养大肠杆菌，并用重组质粒转化，该质粒可表达细胞内 Ralstonia eutropha 的 PHA 解聚酶，从而制备光学纯的 (R)-羟基羧酸。 Ralstonia eutropha 的 PHA 生物合成酶和 藻类 得到(R)-羟基羧酸。本发明制备(R)-羟基羧酸的工艺可通过同时进行 PHA 合成和降解，成功地应用于大规模连续生产过程，生产率高，同时还具有收获细胞和处理细胞废物程序简单的优点。
• METHODS AND PRECURSORS FOR THE PRODUCTION OF CHIRAL VICINAL AMINOALCOHOLS
  申请人：Biocatalytics, Inc.

  公开号：EP0991772A1

  公开（公告）日：2000-04-12
• COMPOSITIONS INCLUDING N-BUTYL 3-HYDROXYBUTYRATE
  申请人：Eastman Chemical Company

  公开号：EP3027696B1

  公开（公告）日：2021-08-18
• AQUEOUS CLEANING COMPOSITIONS INCLUDING AN ALKYL 3-HYDROXYBUTYRATE
  申请人：Eastman Chemical Company

  公开号：EP3027695B1

  公开（公告）日：2019-05-08
• (R)-hydroxycarboxylic acid producing recombinant microorganism and process for preparing (r)-hydroxycarboxylic acid using the same
  申请人：Lee Sang-Yup

  公开号：US20050069995A1

  公开（公告）日：2005-03-31

  The present invention relates to recombinant microorganisms carrying both a gene encoding intracellular polyhydroxyalkanoate (PHA) depolymerase and a gene encoding PHA biosynthesis-related enzymes, and a process for preparing optically pure (R)-hydroxycarboxylic acids by culturing the recombinant microorganisms. The present invention provides: a recombinant microorganism transformed with two recombinant plasmids each of which contains a gene encoding intracellular PHA depolymerase and a gene encoding PHA biosynthesis-related enzymes, respectively; a recombinant microorganism harboring a gene encoding PHA biosynthesis-related enzymes in an integrated form with its chromosome, which is transformed with a recombinant plasmid containing a gene encoding intracellular PHA depolymerase; and, a process for preparing optically pure (R)-hydroxycarboxylic acids by culturing the recombinant microorganisms. In accordance with the present invention, (R)-hydroxycarboxylic acids can be released from the recombinant microorganisms into culture media after depolymerizing most PHA produced from the said microorganisms, which makes possible practical preparation of (R)-hydroxycarboxylic acids in a simple manner with reduced waste of substrates to increase the productivity, finally to allow the mass production of various optically pure (R)-hydroxycarboxylic acids.