| 375824-37-6

• 分子结构分类: 有机化合物
• CAS: 375824-37-6
• 化学式: C₄₇H₇₅N₃O₅SeSi
• 分子量: 869.175
• InChiKey: AIFGCANSVFGBTN-URNAVVNMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.45
• 重原子数：
  57.0
• 可旋转键数：
  15.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  102.75
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  在 2,6-二叔丁基吡啶 、 4 A molecular sieve 、 三氟甲烷磺酸甲酯 作用下， 以 二氯甲烷 为溶剂， 反应 19.0h， 以83%的产率得到acetic acid 4-azido-6-[17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-5-(hydroxy-diisopropyl-silanyloxy)-2-methyl-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  β-Selective Glycosylations with Masked d-Mycosamine Precursors

  摘要：

  [GRAPHICS]Both an intramolecular aglycon delivery (IAD) method and an intermolecular S(N)2 displacement method were examined for beta -selective glycosylations of cholesterol with D-mycosamine. An anomeric sulfoxide, sulfide, selenide, and fluoride were all successfully used as glycosyl donors in IAD reactions. The alpha -bromo ketone 19 was synthesized from protected mycosamine and employed in an intermolecular S(N)2 glycosylation reaction, Both routes were successful for the model alcohol, cholesterol.

  DOI：

  10.1021/ol016617i
• 作为产物：
  描述：

  Acetic acid (2R,3S,4R,5S)-4-azido-5-hydroxy-2-methyl-6-phenylselanyl-tetrahydro-pyran-3-yl ester 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.62h， 生成
  参考文献：
  名称：

  β-Selective Glycosylations with Masked d-Mycosamine Precursors

  摘要：

  [GRAPHICS]Both an intramolecular aglycon delivery (IAD) method and an intermolecular S(N)2 displacement method were examined for beta -selective glycosylations of cholesterol with D-mycosamine. An anomeric sulfoxide, sulfide, selenide, and fluoride were all successfully used as glycosyl donors in IAD reactions. The alpha -bromo ketone 19 was synthesized from protected mycosamine and employed in an intermolecular S(N)2 glycosylation reaction, Both routes were successful for the model alcohol, cholesterol.

  DOI：

  10.1021/ol016617i