2-Pentyl-3-carboxymethyl-cyclopentanol | 705254-27-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Pentyl-3-carboxymethyl-cyclopentanol
• 英文别名: (+/-)-(1R,2R)-3-hydroxy-2-[(2Z)-2-pentenyl]cyclopentaneacetic acid；(+/-)(1R,2R)-3-Hydroxy-2-[(2Z)-2-Pentenyl]Cyclopentaneacetic Acid；2-[(1R,2R)-3-hydroxy-2-[(Z)-pent-2-enyl]cyclopentyl]acetic acid
• CAS: 705254-27-9
• 化学式: C₁₂H₂₀O₃
• 分子量: 212.289
• InChiKey: LYSGIJUGUGJIPS-AOZYTTJRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  茉莉酸 在 sodium tetrahydroborate 作用下， 生成 2-Pentyl-3-carboxymethyl-cyclopentanol
  参考文献：
  名称：

  虎杖的代谢产物

  摘要：

  已经显示出由番茄（Lasiodiplodia theobromae）产生的植物生长抑制剂是茉莉酸（Ia）。从L： theobromae - lasiodiplodin（Va），de - O -methyl-lasiodiplodin（Vb），cis -4-hydroxymellein（XIIIa），吲哚-3-羧酸，3-formylindole和富马酸氢乙酯。也产生（–）-Mellein（XIIIb）。

  DOI：

  10.1039/j39710001623

文献信息

• Compositions comprising jasmonic acid derivatives and use of these derivatives
  申请人：——

  公开号：US20040029839A1

  公开（公告）日：2004-02-12

  Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: 1 wherein: —R 1 is a radical chosen from —COOR′, —CONR′R″, —CH 2 OR′, —COR′, —CH 2 R′, —SO 2 OR′, —PO 3 R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are chosen from a hydrogen atom and saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms, which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms; —R 2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms, as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.

  化妆品或药物组成物包括式(I)化合物及其相应的盐：1其中：- R1是从-COOR'，-CONR'R"，-CH2OR'，-COR'，-CH2R'，-SO2OR'，-PO3R'R"和-NHR'中选择的基团，其中R'和R"（可以相同也可以不同）是选择从1到18个碳原子的饱和和不饱和的线性、支链和环烃基团，这些基团可以通过选择从1到5个相同或不同的实体（例如-OR' "，-OCOR' "，-SR' "，-SCOR' "，NR' "R" "，-NHCOR' "，卤素，-CN，-COOR' "和-COR' "）进行替换，其中R' "和R" "（可以相同也可以不同）是选择从1到4个碳原子的氢原子、芳基基团和饱和和不饱和的线性和支链烃基团；- R2选择从1到18个碳原子的饱和和不饱和的线性、支链和环烃基团，这些基团可以通过选择从1到5个相同或不同的实体（例如-OR' "，-OCOR' "，-SR' "，-SCOR' "，NR' "R" "，-NHCOR' "，卤素，-CN，-COOR' "和-COR' "）进行替换，其中R' "和R" "（可以相同也可以不同）是选择从1到4个碳原子的氢原子、芳基基团和饱和和不饱和的线性和支链烃基团。此外，这些化合物的用途包括促进皮肤角质化、刺激表皮更新和/或对抗皮肤老化迹象。
• USE OF AT LEAST ONE (DIHYDRO)JASMONIC ACID DERIVATIVE FOR TREATING DRY SKIN
  申请人：DALKO Maria

  公开号：US20100015080A1

  公开（公告）日：2010-01-21

  A cosmetic process for treating dry skin and/or a dry scalp of non-inflammatory origin, for example, in a menopausal woman, comprising topically applying to the skin and/or the scalp a composition comprising, in a physiologically acceptable medium, at least one (dihydro)jasmonic acid derivative; novel (dihydro)jasmonic acid derivatives and to the compositions, for example, suitable for topical application to the skin, comprising them.

  一种用于治疗非炎症性干性皮肤和/或干性头皮的美容过程，例如用于更年期妇女，包括将至少一种（二氢）茉莉酸衍生物在生理学可接受的介质中局部涂抹于皮肤和/或头皮上的组合物；以及新型（二氢）茉莉酸衍生物和包含它们的组合物，例如适用于局部涂抹于皮肤的组合物。
• COMPOSITIONS COMPRISING JASMONIC ACID DERIVATIVES AND USE OF THESE DERIVATIVES
  申请人：BOULLE Christophe

  公开号：US20100069497A1

  公开（公告）日：2010-03-18

  Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: —R 1 is a radical chosen from —COOR′, —CONR′R″, —CH 2 OR′, —COR′, —CH 2 R′, —SO 2 OR′, —PO 3 R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; —R 2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.

  配方为(I)式化合物及其对应盐的化妆品或制药组合物，其中：—R1是从—COOR′、—CONR′R″、—CH2OR′、—COR′、—CH2R′、—SO2OR′、—PO3R′R″和—NHR′中选择的基团，其中R′和R″可以相同或不同，如下所定义；—R2选择从1到18个碳原子的饱和和不饱和的线性、支链和环烃基团中选择，该基团可以被从1到5个相同或不同的实体所取代，所述实体从—OR′″、—OCOR′″、—SR′″、—SCOR′″、NR′″R″″、—NHCOR′″、卤素、—CN、—COOR′″和—COR′″中选择，其中R′″和R″″可以相同或不同，如下所定义；此外，这些化合物的用途，例如促进皮肤脱屑、刺激表皮更新和/或对抗皮肤老化的迹象。
• Use of at least one (dihydro)jasmonic acid derivative for treating dry skin
  申请人：Dalko Maria

  公开号：US08461206B2

  公开（公告）日：2013-06-11

  A cosmetic process for treating dry skin and/or a dry scalp of non-inflammatory origin, for example, in a menopausal woman, comprising topically applying to the skin and/or the scalp a composition comprising, in a physiologically acceptable medium, at least one (dihydro)jasmonic acid derivative; novel (dihydro)jasmonic acid derivatives and to the compositions, for example, suitable for topical application to the skin, comprising them.

  一种用于治疗非炎症性干燥皮肤和/或干燥头皮的美容过程，例如用于更年期女性，包括将至少一种（二氢）茉莉酸衍生物在生理接受性介质中制成的组合物局部涂抹于皮肤和/或头皮上；新型（二氢）茉莉酸衍生物及其组合物，例如适合于局部涂抹于皮肤的组合物。
• Compositions comprising jasmonic acid derivatives and use of the derivatives
  申请人：Boulle Christophe

  公开号：US08609117B2

  公开（公告）日：2013-12-17

  Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; —R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.

  化妆品或药物组合物包括公式(I)化合物及其相应的盐，其中：R1是从—COOR′，—CONR′R″，—CH2OR′，—COR′，—CH2R′，—SO2OR′，—PO3R′R″和—NHR′中选择的基团，其中R′和R″（可以相同或不同）在此定义；—R2是从饱和和不饱和的、线性、分支和环烃基中选择的，其中包括1至18个碳原子，可以由1至5个相同或不同的实体（选自—OR′″，—OCOR′″，—SR′″，—SCOR′″，NR′″R″″，—NHCOR′″，卤素，—CN，—COOR′″和—COR′″）进行取代，其中R′″和R″″（可以相同或不同）在此定义；此外，这些化合物的用途，例如促进皮肤脱屑、刺激表皮更新和/或对抗皮肤老化的迹象。