(4R)-5-isopropoxycarbonyl-1,6-dimethyl-3-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-4-phenyl-3,4-dihydropyrimidin-2(1H)-one | 1388627-84-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4R)-5-isopropoxycarbonyl-1,6-dimethyl-3-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
• 英文别名: propan-2-yl (4R)-3-[(2S)-2-(1,3-dioxoisoindol-2-yl)-3-phenylpropanoyl]-1,6-dimethyl-2-oxo-4-phenyl-4H-pyrimidine-5-carboxylate
• CAS: 1388627-84-6
• 化学式: C₃₃H₃₁N₃O₆
• 分子量: 565.626
• InChiKey: WIMLLNIPCZKTKV-XTEPFMGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4R)-5-isopropoxycarbonyl-1,6-dimethyl-3-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 在 lithium aluminium tetrahydride 、 水 、 rochelle salt 作用下， 以 四氢呋喃 为溶剂， 以65%的产率得到(R)-5-isopropoxycarbonyl-1,6-dimethyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
  参考文献：
  名称：

  Chemical resolution of enantiomers of 3,4-dihydropyrimidin-2(1H)-ones using chiral auxiliary approach

  摘要：

  Inherently racemic DHPMs have been resolved using chemical resolution methodology by appending enantiopure chiral auxiliary at N-1 or N-3 position of the DHPMs, leading to the formation of both diastereomers, which were separated chromatographically to obtain both enantiomers (ee upto 99.9%) of DHPMs, after removal of the auxiliary. Absolute configuration of the enantiomers has been assigned. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.05.073
• 作为产物：
  描述：

  i-propyl 1-methyl-6-methyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 、 phthaloyl-L-phenylalanyl chloride 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以45%的产率得到(4S)-5-isopropoxycarbonyl-1,6-dimethyl-3-[(S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenylpropionyl]-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
  参考文献：
  名称：

  Chemical resolution of enantiomers of 3,4-dihydropyrimidin-2(1H)-ones using chiral auxiliary approach

  摘要：

  Inherently racemic DHPMs have been resolved using chemical resolution methodology by appending enantiopure chiral auxiliary at N-1 or N-3 position of the DHPMs, leading to the formation of both diastereomers, which were separated chromatographically to obtain both enantiomers (ee upto 99.9%) of DHPMs, after removal of the auxiliary. Absolute configuration of the enantiomers has been assigned. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.05.073