4-(2-methyl-1-methylcarbamoyl-1H-indol-5-ylamino)-thieno[2,3-b]pyrimidine-6-carboxylic acid ethyl ester | 596794-90-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(2-methyl-1-methylcarbamoyl-1H-indol-5-ylamino)-thieno[2,3-b]pyrimidine-6-carboxylic acid ethyl ester
• 英文别名: Ethyl 4-[[2-methyl-1-(methylcarbamoyl)indol-5-yl]amino]thieno[2,3-d]pyrimidine-6-carboxylate
• CAS: 596794-90-0
• 化学式: C₂₀H₁₉N₅O₃S
• 分子量: 409.469
• InChiKey: FGKQZMOVGDZQRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• INDOLYL-UREA DERIVATIVES OF THIENOPYRIDINES USEFUL AS ANTI-ANGIOGENIC AGENTS
  申请人：PFIZER INC.

  公开号：EP1483268A2

  公开（公告）日：2004-12-08
• [EN] INDOLYL-UREA DERIVATIVES OF THIENOPYRIDINES USEFUL AS ANTI-ANGIOGENIC AGENTS, AND METHODS FOR THEIR USE<br/>[FR] DERIVES INDOLYL-UREE DE THIENOPYRIDINES UTILISES COMME AGENTS ANTIANGIOGENIQUES, ET LEURS METHODES D'UTILISATION
  申请人：PFIZER

  公开号：WO2003074529A2

  公开（公告）日：2003-09-12

  The invention relates to compounds represented by the formula FI and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein X, R1 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.