4-(3,4-Dimethyl-naphthalen-1-yl)-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione | 910116-12-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 4-(3,4-Dimethyl-naphthalen-1-yl)-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione
• CAS: 910116-12-0
• 化学式: C₁₅H₁₅N₃S
• 分子量: 269.37
• InChiKey: MGPOVXMQYFKVTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.01
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  33.61
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(3,4-Dimethyl-naphthalen-1-yl)-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione 、 N-(2-溴-苯基)-2-氯-乙酰胺 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-(2-Bromo-phenyl)-2-[4-(3,4-dimethyl-naphthalen-1-yl)-5-methyl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetamide
  参考文献：
  名称：

  Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase

  摘要：

  A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthio-semicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.06.048
• 作为产物：
  描述：

  1-(1-ethoxy-ethylidene)-thiosemicarbazide 、 1-Amino-3,4-dimethylnaphthalene 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 4-(3,4-Dimethyl-naphthalen-1-yl)-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione
  参考文献：
  名称：

  Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase

  摘要：

  A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthio-semicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.06.048