methyl 2-ethyl-2-hydroxyoct-3-ynoate | 1316843-28-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 2-ethyl-2-hydroxyoct-3-ynoate
• CAS: 1316843-28-3
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: MCNYCRWDFAXMPQ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  methyl 2-ethyl-2-hydroxyoct-3-ynoate 在 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 methyl 4-butyl-5-(1-methoxy-1-oxobutan-2-yl)furan-3-carboxylate
  参考文献：
  名称：

  Microwave-Assisted Domino Access to C₂-Chain Functionalized Furans from Tertiary Propargyl Vinyl Ethers

  摘要：

  Tertiary propargyl vinyl ethers armed with an electron-withdrawing group (amide or ester) at the tertiary propargylic position have been efficiently transformed Into trisubstituted C-2-chain functionalized furans. The metal-free domino transformation Involves a microwave-assisted tandem [3,3]propargyl Claisen rearrangement/5-exo-dig O-cyclization reaction. The manifold can be performed In a one-pot fashion from the primary components (1,2-ketoester/1,2-ketoamide or tertiary propargyl alcohols).

  DOI：

  10.1021/ol2017609