| 1101770-69-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• CAS: 1101770-69-7
• 化学式: C₃₂H₃₆Cl₂N₂
• 分子量: 519.557
• InChiKey: AFWWICDZLXWMDM-YHYNAULMSA-N

反应信息

• 作为产物：
  描述：

  在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Structure–activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough

  摘要：

  A series of 3-axial-aminomethyl-N-benzhydryl-nortropane analogs have been synthesized and identified to bind to the nociceptin receptor with high affinity. Many of these analogs showed high binding selectivity over classic opioid receptors such as l receptor. The synthesis and structure-activity relationships around the C-3 nortropane substitution are described. Selected compounds with potent oral antitussive activity in the guinea pig model are disclosed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.088