ethyl 6,8-dimethoxy-1-phenylpyrrolo[3,2,1-hi]indole-4-carboxylate | 1100050-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: ethyl 6,8-dimethoxy-1-phenylpyrrolo[3,2,1-hi]indole-4-carboxylate
• CAS: 1100050-29-0
• 化学式: C₂₁H₁₉NO₄
• 分子量: 349.386
• InChiKey: XYYHRIZVJYJPQV-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  ethyl 4,6-dimethoxy-7-formyl-3-phenylindol-1-ylacetate 在 sodium hydride 作用下， 以 四氢呋喃 、 paraffin oil 为溶剂， 反应 2.0h， 以60%的产率得到ethyl 6,8-dimethoxy-1-phenylpyrrolo[3,2,1-hi]indole-4-carboxylate
  参考文献：
  名称：

  Effective synthetic routes to activated pyrrolo[3,2,1-hi]indoles

  摘要：

  Pyrrolo[3,2,1-hi]indoles have been formed by the aldol cyclisation of 7-formyl-N-indolylacetates. The synthetic sequence incorporates three steps from suitably activated indoles: these are alkylation at nitrogen with a bromoacetic ester, formylation at C7 and an aldol condensation between these two substituents. Art X-ray crystal structure of pyrrolo[3,2,1-hi]indole 24 is described. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.10.025