6-amino-4-n-hexyl-N³,N⁵-di-o-tolyl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide | 1453263-57-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-amino-4-n-hexyl-N³,N⁵-di-o-tolyl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide
• CAS: 1453263-57-4
• 化学式: C₂₇H₃₄N₄O₂S
• 分子量: 478.659
• InChiKey: FHYBEPXKTLCBNP-UHFFFAOYSA-N

物化性质

• 熔点：
  188-190 °C(Solvent: Ethanol)
• 密度：
  1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  6-amino-4-n-hexyl-N³,N⁵-di-o-tolyl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 24.17h， 以58%的产率得到2-amino-6-benzylsulfanyl-4-n-hexyl-N³,N⁵-di-o-tolyl-3,4-dihydropyridine-3,5-dicarboxamide
  参考文献：
  名称：

  4-alkyl-6-amino-4-N 3,N 5-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides: I. Tandem synthesis and alkylation. Molecular and crystal structure of 6-allylsulfanyl-2-amino-4-isobutyl-N 3,N 5-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide

  摘要：

  4-Alkyl-6-amino-4-N (3),N (5)-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides were obtained via tandem synthesis involving the Knoevenagel reaction, Michael reaction and intramolecular condensation. Alkylation of the obtained dicarboxamides proceeds regioselectively at the S atom to form the corresponding thioethers. Structure of 6-allylsulfanyl-2-amino-4-isobutyl-N (3),N (5)-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide was uniquely determined by XRD analysis.

  DOI：

  10.1134/s1070363213070153
• 作为产物：
  描述：

  庚醛 在 乙醇 、 sodium ethanolate 、 sodium 作用下， 反应 48.17h， 生成 6-amino-4-n-hexyl-N³,N⁵-di-o-tolyl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamide
  参考文献：
  名称：

  4-alkyl-6-amino-4-N 3,N 5-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides: I. Tandem synthesis and alkylation. Molecular and crystal structure of 6-allylsulfanyl-2-amino-4-isobutyl-N 3,N 5-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide

  摘要：

  4-Alkyl-6-amino-4-N (3),N (5)-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides were obtained via tandem synthesis involving the Knoevenagel reaction, Michael reaction and intramolecular condensation. Alkylation of the obtained dicarboxamides proceeds regioselectively at the S atom to form the corresponding thioethers. Structure of 6-allylsulfanyl-2-amino-4-isobutyl-N (3),N (5)-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide was uniquely determined by XRD analysis.

  DOI：

  10.1134/s1070363213070153