3-(2-[4-(chromen-2-one-3-yl)thiazol-2-yl]thiazol-4-yl)-chromen-2-one | 319491-51-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(2-[4-(chromen-2-one-3-yl)thiazol-2-yl]thiazol-4-yl)-chromen-2-one
• 英文别名: 3-[2-[[4-(2-Oxochromen-3-yl)-1,3-thiazol-2-yl]methyl]-1,3-thiazol-4-yl]chromen-2-one
• CAS: 319491-51-5
• 化学式: C₂₅H₁₄N₂O₄S₂
• 分子量: 470.529
• InChiKey: YIDSYDZVGVUUSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  135
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  dithiomalonamide 、 3-(溴乙酰基)香豆素 以 N,N-二甲基甲酰胺 为溶剂， 以71%的产率得到3-(2-[4-(chromen-2-one-3-yl)thiazol-2-yl]thiazol-4-yl)-chromen-2-one
  参考文献：
  名称：

  Cyanoselenoacetamide in a new synthesis of propane-bis(thioamide), the promising reagent for heterocyclizations

  摘要：

  Cyanoselenoacetamide reacts with hydrogen sulfide to form propane-bis(thioamide), which can be used to produce thiazoles (the Hantzsch synthesis) and 3-thioxo-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile. From the latter compound, 2-alkylsulfanyl-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles and 1-amino-N-(4-bromophenyl)-5-phenyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide can be prepared.

  DOI：

  10.1134/s1070363213090168

文献信息

• Methods and compositions for inhibiting mutant EGFR signaling
  申请人：The Governing Council of the University of Toronto

  公开号：US11123330B2

  公开（公告）日：2021-09-21

  Methods of inhibiting mutant EGFR and methods of treating a subject afflicted with a lung cancer having a mutant EGFR, having for example a C797 mutation, are described. The methods comprise administering to a cell or a subject in need thereof a therapeutically effective amount of a compound selected from 3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one and a structurally related analog thereof; midostaurin; and AZD7622 and a structurally related analog thereof; and mixtures thereof. Compositions and combinations comprising the compounds of the disclosure as well as uses are also provided.

  本发明描述了抑制突变表皮生长因子受体的方法和治疗具有突变表皮生长因子受体（例如具有C797突变）的肺癌患者的方法。这些方法包括向细胞或有需要的受试者施用治疗有效量的选自3-(1,3-苯并恶唑-2-基)-7-(二乙氨基)-2H-色烯-2-酮及其结构相关类似物、米多司他林、AZD7622及其结构相关类似物和它们的混合物的化合物。还提供了包含本公开化合物的组合物和组合物以及用途。
• Cyanoselenoacetamide in a new synthesis of propane-bis(thioamide), the promising reagent for heterocyclizations
  作者：I. V. Dyachenko、M. V. Vovk

  DOI：10.1134/s1070363213090168

  日期：2013.9

  Cyanoselenoacetamide reacts with hydrogen sulfide to form propane-bis(thioamide), which can be used to produce thiazoles (the Hantzsch synthesis) and 3-thioxo-1-phenyl-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile. From the latter compound, 2-alkylsulfanyl-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitriles and 1-amino-N-(4-bromophenyl)-5-phenyl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide can be prepared.