chlorohydrate de 2-acetoxyacetimidate d'ethyle | 133915-16-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: chlorohydrate de 2-acetoxyacetimidate d'ethyle
• 英文别名: ethyl 2-acetoxyacetimidate hydrochloride；2-ethoxy-2-iminoethyl acetate hydrochloride；2-Ethoxy-2-iminoethyl acetate hydrogen chloride salt；(2-ethoxy-2-iminoethyl) acetate;hydrochloride
• CAS: 133915-16-9
• 化学式: C₆H₁₁NO₃*ClH
• 分子量: 181.619
• InChiKey: VEIMRILVJYYVQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.99
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  59.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  chlorohydrate de 2-acetoxyacetimidate d'ethyle 、 2-氨基-3-氨基甲基吡嗪 以 乙醇 为溶剂， 以41%的产率得到2-(hydroxymethyl)-3,4-dihydropteridine
  参考文献：
  名称：

  Synthèse et activité hypo-uricémiante de nouvelles ptéridines

  摘要：

  A series of new pteridines and 3,4-dihydropteridines with substitution in position 2, showed a hypouricemic activity in rats. After a single oral administration in this species, the hypouricemic effect of 2-(methoxymethoxymethyl)-3,4-dihydropteridine maleate 26b and 2-(2,2,2-trifluoroethoxymethyl)-3,4-dihydropteridine maleate 32b is as potent as that of 1H-pyrazolo[3,4-d]pyrimidin-4-ol (allopurinol). We showed a long-lasting fall of uricemia in further investigation of compound 26b; this fall can reach 80%. Compound 26b, unlike allopurinol, is not an in vitro xanthine oxidase inhibitor, but the ex vivo inhibition could be proved. It could be useful in the treatment of fout in human beings.

  DOI：

  10.1016/0223-5234(92)90144-p
• 作为产物：
  描述：

  氰基甲基乙酸酯 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 chlorohydrate de 2-acetoxyacetimidate d'ethyle
  参考文献：
  名称：

  4(3H)-pteridinones, preparation processes and drugs containing them

  摘要：

  本发明涉及具有以下通式的4(3H)-蝶啶酮：##STR1##其中X是氧原子或硫原子，Y是氢原子、低级烷基基团，特别是6位上的甲基基团或7位上的羟基基团，R1是氢原子、低级烷基基团、取代或未取代的苯基基团、苄基基团、甲氧基甲基基团、乙酰基基团、2-乙酸氧乙基基团或2,2,2-三氟乙基基团，R2是氢原子或低级烷基基团，特别是甲基基团。这些化合物作为抗过敏药物的应用。

  公开号：

  US05167949A1

文献信息

• HETEROCYCLES USEFUL AS INHIBITORS OF CARBONIC ANHYDRASE
  申请人：Chong Wesley Kwan Mung

  公开号：US20100256357A1

  公开（公告）日：2010-10-07

  Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.

  本文披露了磺胺类化合物及其药物组合物的制备方法，这些化合物对于控制眼压具有有用的作用。本文还披露了通过给予这些药物组合物来控制眼压的方法。
• WO2008/17932
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis and potential antiallergic activity of new pteridinones and related compounds
  作者：G Ferrand、H Dumas、JC Depin、Y Quentin

  DOI：10.1016/0223-5234(96)80364-3

  日期：1996.1

  The synthesis and pharmacological profile of a series of 2-alkoxy and 2-phenoxymethyl-3H-pteridin-4-ones and related compounds are described. These compounds displayed antiallergic activity in the passive cutaneous anaphylaxis test in rats. In contrast to both sodium cromoglycate and nedocromil sodium, many of our compounds were active when administered orally. The most potent in this series, 2-ethoxymethyl-3H-pteridin-4-one 2b (LCB 2183) was investigated in other models of allergy and inflammation. The antiallergic activity was confirmed and interesting antiinflammatory properties were observed. It was therefore selected for further development as a human therapeutic agent.
• US5167949A
  申请人：——

  公开号：US5167949A

  公开（公告）日：1992-12-01
• US5270465A
  申请人：——

  公开号：US5270465A

  公开（公告）日：1993-12-14