(Z)-5-(4-methoxyphenyl)methylene-2,4-thiazolidinedithione | 32723-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (Z)-5-(4-methoxyphenyl)methylene-2,4-thiazolidinedithione
• 英文别名: (5z)-5-(4-Methoxybenzylidene)-1,3-thiazolidine-2,4-dithione；(5Z)-5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dithione
• CAS: 32723-28-7
• 化学式: C₁₁H₉NOS₃
• 分子量: 267.397
• InChiKey: FUEFKSDMWYHMBY-TWGQIWQCSA-N

物化性质

• 沸点：
  418.1±55.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-5-(4-methoxyphenyl)methylene-2,4-thiazolidinedithione 以73%的产率得到
  参考文献：
  名称：

  KASSAB NAZMI ABD EL LATIF; ABD ALLAH SANAA OSMAN; EAD HAMED ABD EL REHEEM, Z. NATURFORSCH. , 1975, 306, NO 3, 441-445

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 1,3-噻唑烷-2,4-二硫酮 在 polyethylene glycol-400 作用下， 以80%的产率得到(Z)-5-(4-methoxyphenyl)methylene-2,4-thiazolidinedithione
  参考文献：
  名称：

  A simple green synthesis of (Z)-5-arylmethylene-4- thioxothiazolidines and thiopyrano[2,3-d]thiazolidine-2-thiones in PEG-400 under catalyst-free conditions

  摘要：

  DOI：

  10.1080/17415993.2014.933341

文献信息

• Ead, Hamed Abdel Reheem; Kassab, Nazmi Abdel Latif; Koeppel, Hubert, Journal fur praktische Chemie (Leipzig 1954), 1980, vol. 322, # 1, p. 155 - 160
  作者：Ead, Hamed Abdel Reheem、Kassab, Nazmi Abdel Latif、Koeppel, Hubert、Bloedorn, Wolf-Dieter、Schleinitz, Klaus-Dieter

  DOI：——

  日期：——
• VYUNOV K. A.; GINAK A. I.; SOCHILIN E. G., ZH. ORGAN. XIMII, 1979, 15, HO 6, 1302-1305
  作者：VYUNOV K. A.、 GINAK A. I.、 SOCHILIN E. G.

  DOI：——

  日期：——
• EAD, HAMED A.;ADBALLAH, SANAA O.;KASSAB, NAZMI A.;METWALLI, NADIA H., SULFUR LETT. , 9,(1989) N-2, C. 23-32
  作者：EAD, HAMED A.、ADBALLAH, SANAA O.、KASSAB, NAZMI A.、METWALLI, NADIA H.

  DOI：——

  日期：——
• [EN] RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS<br/>[FR] DERIVES DE RHODANINE UTILES POUR LE TRAITEMENT ET LA PREVENTION DE TROUBLES METABOLIQUES DES OS
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO2000018748A1

  公开（公告）日：2000-04-06

  The object of the present invention are compounds of general formula (I), in which m signifies a number between 0 and 8; q signifies a number between 0 and 8; X signifies the group CH2 or C=S, whereby A signifies a single bond and m signifies 0 when X signifies CH2; A signifies a single or double bond; R1, R2 signify hydrogen or lower alkyl, whereby R1 and R2 can be the same or different and, when m signifies 2-8, R1 and R2 in the group CR1=CR2 can have various significances within the following sequence; R3 signifies hydrogen or lower alkyl; Z signifies oxygen, sulphur; W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain one or more hetero atoms, as well as their physiologically compatible salts, esters, optically active forms, racemates, tautomers, as well as derivatives which can be metabolized in vivo to compounds of general formula (I), as well as the use of these compounds for the production of medicaments for the prophylaxis or therapy of metabolic bone disorders.
• A simple green synthesis of (<i>Z</i>)-5-arylmethylene-4- thioxothiazolidines and thiopyrano[2,3-<i>d</i>]thiazolidine-2-thiones in PEG-400 under catalyst-free conditions
  作者：Nadia Hanafy Metwally

  DOI：10.1080/17415993.2014.933341

  日期：2014.9.3