N-(2,5-diethoxy-4-morpholinophenyl)-N-(4-methylbenzenesulfonyl)-4-methylbenzenesulfonamide | 1614214-47-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-(2,5-diethoxy-4-morpholinophenyl)-N-(4-methylbenzenesulfonyl)-4-methylbenzenesulfonamide
• 英文别名: N-(2,5-diethoxy-4-morpholin-4-ylphenyl)-4-methyl-N-(4-methylphenyl)sulfonylbenzenesulfonamide
• CAS: 1614214-47-9
• 化学式: C₂₈H₃₄N₂O₇S₂
• 分子量: 574.719
• InChiKey: ORWTUHCNXBWBBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  119
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  对甲苯亚磺酸 、 2,5-二乙氧基-4-吗啉基苯胺 以 aq. phosphate buffer 、 乙腈 为溶剂， 以63%的产率得到N-(2,5-diethoxy-4-morpholinophenyl)-N-(4-methylbenzenesulfonyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Electrochemical Synthesis of Sulfonamide Derivatives Based on the Oxidation of 2,5-Diethoxy-4-Morpholinoaniline in the Presence of Arylsulfinic Acids

  摘要：

  Some new sulfonamide derivatives were synthesized in aqueous solutions via anodic oxidation of 2,5-diethoxy-4-morpholinoaniline in the presence of arylsulfinic acids using a commercial carbon anode. In addition, the formation mechanism of the products was discussed. The obtained data show that the electrogenerated quinone diimine undergoes a Michael-type addition reaction with arylsulfinic acids to yield the respective sulfonamide derivatives. In this work, two different types of products (mono- and disulfone derivatives) in the same precursor could be isolated just by controlling the exerted potentials.

  DOI：

  10.1021/jo500812d