N-methylmorpholinium formate | 92867-42-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: N-methylmorpholinium formate
• 英文别名: [Mmorph][F]；N-methyl-morpholinium formate；4-methylmorpholin-4-ium;formate
• CAS: 92867-42-0
• 化学式: CH₂O₂*C₅H₁₁NO
• 分子量: 147.174
• InChiKey: QRSLOWGOGVHIKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.35
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基吗啉 、 甲酸 反应 24.0h， 生成 N-methylmorpholinium formate
  参考文献：
  名称：

  质子吗啉基离子液体表面性质的实​​验研究

  摘要：

  在这项工作中，合成了十种具有烷基羧酸根阴离子的新型质子吗啉基离子液体（ILs），其密度和表面张力的测量范围为298.15至348.15K。该设备有助于在水含量极低且没有水蒸气的情况下在液/气界面进行测量。在相同条件下也测量了弯液面接触角。每个IL的表面张力表现出与温度的高度线性相关性，从而可以准确评估表面热力学函数（表面熵和表面能）。根据表面张力值，通过古根希姆（Guggenhiem）和Eötvös方程估算临界点。表面张力，

  DOI：

  10.1016/j.molliq.2017.06.045

文献信息

• Chemical process for the preparation of intermediates to obtain n-formyl hydroxy-lamine compounds
  申请人：Prashad Mahavir

  公开号：US20070179298A1

  公开（公告）日：2007-08-02

  Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular β-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxy-propionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.

  改进的工艺用于制备中间体，有助于制备抗菌N-[1-氧代-2-烷基-3-(N-羟基甲酰胺基)-丙基}-(羰基氨基-芳基或杂环芳基)-氮杂环4-7烷或硫杂环4-7烷，具有以下一项或多项特征：（1）利用特定的β-内酰胺中间体；（2）利用特定的分离剂，对映异构纯取代丙酸，特别是（R）-2-丁基-3-羟基-丙酸；（3）避免使用过氧化氢；（4）有助于选择性脱苄基，减少废弃产物的产生。
• CHEMICAL PROCESS FOR THE PREPARATION OF INTERMEDIATES TO OBTAIN N-FORMYL HYDROXYLAMINE COMPOUNDS
  申请人：Prashad Mahavir

  公开号：US20090131707A1

  公开（公告）日：2009-05-21

  Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular I3-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxypropionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.

  改进的过程用于制备中间体，用于制备具有以下特征的抗菌N-[1-氧代2-烷基-3-(N-羟基甲酰胺基)丙基}-(羰基氨基芳基或杂芳基)-氮杂环4-7烷或硫杂环4-7烷：(1)利用特定的I3-内酰胺中间体；(2)利用特定的分离剂，对映异构体纯度替代丙酸，特别是（R）-2-丁基-3-羟基丙酸；(3)避免使用过氧化氢；和(4)有助于选择性脱苯基还原产生的废弃副产物。
• Process to obtain a tetrahydroisoquinoline derivative
  申请人：Medichem S.A.

  公开号：US11001574B2

  公开（公告）日：2021-05-11

  The present invention relates to a process for preparing lifitegrast or a salt thereof, wherein the process comprises hydrogenation of compound II in a mixture comprising at least one solvent selected from the group consisting of acetonitrile, a ketone solvent, an ester solvent and a mixture thereof, preferably acetonitrile.

  本发明涉及一种制备利维拉斯特或其盐的工艺，其中该工艺包括化合物 II 在一种混合物中的氢化，该混合物包含至少一种溶剂，该溶剂选自由乙腈、酮类溶剂、酯类溶剂及其混合物组成的组，优选乙腈。
• Physicochemical Characterization of Morpholinium Cation Based Protic Ionic Liquids Used As Electrolytes
  作者：Catherine Brigouleix、Mérièm Anouti、Johan Jacquemin、Magali Caillon-Caravanier、Hervé Galiano、Daniel Lemordant

  DOI：10.1021/jp906917v

  日期：2010.2.11

  New protic ionic liquids (PILs) based on the morpholinium, N-methylmorpholinium, and N-ethyl morpholinium cations have been synthesized through a simple and atom-economic neutralization reaction between N-alkyl morpholine and formic acid. Their densities, refractive indices, thermal properties, and electrochemical windows have been measured. The temperature dependence of their dynamic viscosity and ionic conductivity have also been determined. The results allow us to classify them according to a classical Walden diagram and to evaluate their "fragility". In addition, morpholinium based PILs exhibit a large electrochemical window as compared to other protic ionic liquids (up 2.91 V) and possess relatively high ionic conductivities of 10-16.8 mS.cm(-1) at 25 degrees C and 21-29 mS.cm(-1) at 100 degrees C, and a residual conductivity close to 1.0 mS.cm(-1) at - 15 degrees C. PIL-water Mixtures exhibit high ionic conductivities up to 65 mS.cm(-1) at 25 degrees C and 120 mS.cm(-1) at 100 degrees C for morpholinium formate with water weight fraction w(w) = 0.6. Morpholinium based PILs studied in this work have a low cost and low toxicity, are good ionic liquids, and prove extremely fragile. They have wide applicable perspectives as electrolytes for fuel cell devices, thermal transfer fluids, and acid-catalyzed reaction media as replacements of conventional solvents.
• PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES
  申请人：PARKE-DAVIS

  公开号：EP0980374A1

  公开（公告）日：2000-02-23