| 133249-76-0

• 分子结构分类: 有机化合物
• CAS: 133249-76-0
• 化学式: C₄H₁₆N₂O₂Pt
• 分子量: 323.231
• InChiKey: QGVIROGXNNIDEJ-JBISRTOLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  、 重水 、 2'-脱氧鸟苷 以 重水 为溶剂， 生成 、 、
  参考文献：
  名称：

  Asymmetrical complexes [Pt(N,N-dmen)(dGuo)L](2)+ (N,N-dmen=N,N-dimethylethylenediamine; L=H2O, Cl−, dGuo): H8 nuclei experience an orientation-dependent deshielding effect attributable to the paramagnetic anisotropy of the platinum atom

  摘要：

  N7 coordination of deoxyguanosine (dGuo) to platinum(II) is known to shift the NMR signal of the guanine H8 proton downfield. The amplitude of this downfield shift depends on the platinum ligands and their configuration. We show here that the guanine H8 chemical shift variation upon coordination of dGuo to [Pt(N,N-dmen)(H2O)(2)](2+) (N,N-dmen = N,N-dimethylethylenediamine) or to [PtCl(N,N-dmen)(H2O)] is 0.2-0.3 ppm larger when dGuo binds cis to the NMe2 group than when it coordinates the site cis to the NH2 group. This difference can be explained by sterical restrictions imposed by the bulky NMe2 group to a cis-guanine, forcing it into an orientation approximately perpendicular to the coordination plane. In this position, the H8 proton apparently experiences a downfield shift arising from the paramagnetic anisotropy of the platinum(II) atom. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0020-1693(99)00413-2
• 作为产物：
  描述：

  (SP-4-3)-dichlorido(N,N-dimethylethane-1,2-diamine)platinum(II) 、 重水 在 AgNO₃ 作用下， 以 重水 为溶剂， 生成
  参考文献：
  名称：

  Asymmetrical complexes [Pt(N,N-dmen)(dGuo)L](2)+ (N,N-dmen=N,N-dimethylethylenediamine; L=H2O, Cl−, dGuo): H8 nuclei experience an orientation-dependent deshielding effect attributable to the paramagnetic anisotropy of the platinum atom

  摘要：

  N7 coordination of deoxyguanosine (dGuo) to platinum(II) is known to shift the NMR signal of the guanine H8 proton downfield. The amplitude of this downfield shift depends on the platinum ligands and their configuration. We show here that the guanine H8 chemical shift variation upon coordination of dGuo to [Pt(N,N-dmen)(H2O)(2)](2+) (N,N-dmen = N,N-dimethylethylenediamine) or to [PtCl(N,N-dmen)(H2O)] is 0.2-0.3 ppm larger when dGuo binds cis to the NMe2 group than when it coordinates the site cis to the NH2 group. This difference can be explained by sterical restrictions imposed by the bulky NMe2 group to a cis-guanine, forcing it into an orientation approximately perpendicular to the coordination plane. In this position, the H8 proton apparently experiences a downfield shift arising from the paramagnetic anisotropy of the platinum(II) atom. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0020-1693(99)00413-2