N1-(biphenyl-3-yl)-N7-sulfamoylheptanediamide | 1110637-90-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N1-(biphenyl-3-yl)-N7-sulfamoylheptanediamide
• 英文别名: N-(3-phenylphenyl)-N'-sulfamoylheptanediamide
• CAS: 1110637-90-5
• 化学式: C₁₉H₂₃N₃O₄S
• 分子量: 389.475
• InChiKey: ATDSPUBXMLTPNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  庚二酸氢乙酯 在 水 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 磺酰胺 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 、 N,N'-羰基二咪唑 、 lithium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 N1-(biphenyl-3-yl)-N7-sulfamoylheptanediamide
  参考文献：
  名称：

  Sulfamides as novel histone deacetylase inhibitors

  摘要：

  The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.081

文献信息

• Sulfamides as novel histone deacetylase inhibitors
  作者：Amal Wahhab、David Smil、Alain Ajamian、Martin Allan、Yves Chantigny、Eric Therrien、Natalie Nguyen、Sukhdev Manku、Silvana Leit、Jubrail Rahil、Andrea J. Petschner、Ai-Hua Lu、Alina Nicolescu、Sylvain Lefebvre、Samuel Montcalm、Marielle Fournel、Theresa P. Yan、Zuomei Li、Jeffrey M. Besterman、Robert Déziel

  DOI：10.1016/j.bmcl.2008.11.081

  日期：2009.1

  The sulfamide moiety has been utilized to design novel HDAC inhibitors. The potency and selectivity of these inhibitors were influenced both by the nature of the scaffold, and the capping group. Linear long-chain-based analogs were primarily HDAC6-selective, while analogs based on the lysine scaffold resulted in potent HDAC1 and HDAC6 inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.