5-(2,3-Diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-pentanoic acid | 871465-27-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(2,3-Diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-pentanoic acid
• 英文别名: 5-(2,3-diazabicyclo[2.2.1]hept-2-en-7-ylidene)pentanoic acid
• CAS: 871465-27-9
• 化学式: C₁₀H₁₄N₂O₂
• 分子量: 194.233
• InChiKey: DWARUHNZXOCCOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  62.02
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  5-(2,3-Diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-pentanoic acid 、 1-甲基-3-硝基-1-亚硝基胍 在 氢氧化钾 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 以35%的产率得到
  参考文献：
  名称：

  Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals

  摘要：

  A combination of (ROMP) ring-opening metathesis polymerization and diradical (diyl) cross-linking provides a new access to hard biomaterials and potential artificial bone replacements. ROMP was used to construct soft and pliable linear polymers bearing photolabile diazene functions. After treatment with light, a nitrogen aerosol is released throughout the polymer to create desirable porosity, cross-linking, and hardening in a single step. Nonpolymeric mechanistic work supporting these studies was also examined. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.060
• 作为产物：
  描述：

  methyl 5-(cyclopenta-2,4-dien-1-ylidene)pentanoate 在 potassium diazodicarboxylate 、 potassium carbonate 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 7.5h， 生成 5-(2,3-Diaza-bicyclo[2.2.1]hept-2-en-7-ylidene)-pentanoic acid
  参考文献：
  名称：

  Photocurable hard and porous biomaterials from ROMP precursors cross-linked with diyl radicals

  摘要：

  A combination of (ROMP) ring-opening metathesis polymerization and diradical (diyl) cross-linking provides a new access to hard biomaterials and potential artificial bone replacements. ROMP was used to construct soft and pliable linear polymers bearing photolabile diazene functions. After treatment with light, a nitrogen aerosol is released throughout the polymer to create desirable porosity, cross-linking, and hardening in a single step. Nonpolymeric mechanistic work supporting these studies was also examined. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.060