6-(hex-1-ynyl)nicotinic acid ethyl ester | 849132-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(hex-1-ynyl)nicotinic acid ethyl ester
• 英文别名: ethyl 6-hex-1-ynylpyridine-3-carboxylate
• CAS: 849132-05-4
• 化学式: C₁₄H₁₇NO₂
• 分子量: 231.294
• InChiKey: DGXMWGBFBJAYSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(hex-1-ynyl)nicotinic acid ethyl ester 在 4-二甲氨基吡啶 、 氢氧化钾 、 2,4,6-三氯苯甲酰氯 、 氨 、 sodium 、 三乙胺 、 copper(l) chloride 作用下， 以 四氢呋喃 、 N,N-二甲基乙酰胺 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 32.0h， 生成 3-Propyl-5,6-dihydro-indolizine-6-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Selective Partial Reduction of Various Heteroaromatic Compounds with Bridgehead Nitrogen via Birch Reduction Protocol

  摘要：

  [GRAPHICS]For the first time various heteroaromatic compounds with bridgehead nitrogen, including indolizines, bispyrrolopyrimidines, pyrroloquinolines, pyrroloisoquinolines, and bispyrrolopyrazines, were selectively partially reduced under Birch reduction conditions. It was found that the double bond in the fused heterocycles which possesses the highest LUMO density can be selectively reduced under these conditions. Indolizine 6, containing an ester group at C-6, was reductively alkylated to give dihydroindolizines 8 and 9 possessing a quaternary carbon center in good yield. It was found that ambident substrate 12, under Birch reduction conditions, underwent smooth partial reduction to give 4,5-dihydroquinoline 14 as a sole product with no evidence of reduction of the side chain olefin. It was also shown that electron-rich pyrroloisoquinoline 15, which cannot be reduced via catalytic hydrogenation conditions, was efficiently transformed into its dihydrocounterpart 16 by using the Birch reduction protocol. Finally, it was shown that various fused diazines were smoothly and stereoselectively reduced under Birch reduction conditions to give trans-4,5-disubstituted dihydropyrimidines 30 and 32 in virtually quantitative yields.

  DOI：

  10.1021/jo0479157
• 作为产物：
  描述：

  6-氯烟酸乙酯 、 1-己炔 在 bis-triphenylphosphine-palladium(II) chloride 、 三乙胺 copper(l) iodide 、 N,N-二异丙基乙胺 、 三苯基膦 作用下， 反应 12.0h， 以94%的产率得到6-(hex-1-ynyl)nicotinic acid ethyl ester
  参考文献：
  名称：

  Selective Partial Reduction of Various Heteroaromatic Compounds with Bridgehead Nitrogen via Birch Reduction Protocol

  摘要：

  [GRAPHICS]For the first time various heteroaromatic compounds with bridgehead nitrogen, including indolizines, bispyrrolopyrimidines, pyrroloquinolines, pyrroloisoquinolines, and bispyrrolopyrazines, were selectively partially reduced under Birch reduction conditions. It was found that the double bond in the fused heterocycles which possesses the highest LUMO density can be selectively reduced under these conditions. Indolizine 6, containing an ester group at C-6, was reductively alkylated to give dihydroindolizines 8 and 9 possessing a quaternary carbon center in good yield. It was found that ambident substrate 12, under Birch reduction conditions, underwent smooth partial reduction to give 4,5-dihydroquinoline 14 as a sole product with no evidence of reduction of the side chain olefin. It was also shown that electron-rich pyrroloisoquinoline 15, which cannot be reduced via catalytic hydrogenation conditions, was efficiently transformed into its dihydrocounterpart 16 by using the Birch reduction protocol. Finally, it was shown that various fused diazines were smoothly and stereoselectively reduced under Birch reduction conditions to give trans-4,5-disubstituted dihydropyrimidines 30 and 32 in virtually quantitative yields.

  DOI：

  10.1021/jo0479157