N-[(1-Carboxy-3-phenylpropyl)-α-azaglycyl]-4(R)-carboxy-2-(2-hydroxyphenyl)thiazolidine | 79625-89-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(1-Carboxy-3-phenylpropyl)-α-azaglycyl]-4(R)-carboxy-2-(2-hydroxyphenyl)thiazolidine
• 英文别名: 3-[2-[(1-Carboxy-3-phenylpropyl)amino]acetyl]-2-(2-hydroxyphenyl)-1,3-thiazolidine-4-carboxylic acid
• CAS: 79625-89-1
• 化学式: C₂₂H₂₄N₂O₆S
• 分子量: 444.508
• InChiKey: GCLGWVQKQQQFRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives
  申请人：Merck & Co., Inc.

  公开号：EP0059966A1

  公开（公告）日：1982-09-15

  There are disclosed substituted arylthiazolidine carboxylic acid analogs, derivatives and related compounds of the formula: wherein: R and R3 are the same or different and are hydrogen, loweralkyl, aralkyl; R, is alkyl of from one to ten carbon atoms which include, branched, cyclic and unsaturated alkyl groups; substituted alkyl of from one to six carbon atoms wherein the substituent is amino, arylthio, aryloxy, hydroxy, arylamino, and acylamino; or alkyl and heteroaralkyl optionally substituted by halo, loweralkyl, hydroxy, aminoloweralkyl, alkoxy and amino groups and wherein the alkyl group contains from one to six carbon atoms; R2 is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group selected from the group consisting of phenyl, naphthyl, or biphenyl wherein the substituent is hydroxyl or lower alkyloxy; X is CH2 or S; and, the pharmaceutically acceptable salts thereof as well as processes for preparing the same. These compounds are angiotensin converting enzyme inhibitors which are useful for treating hypertension.

  公开了取代的芳基噻唑烷羧酸类似物、衍生物和相关化合物，其式如下 其中 R和R3相同或不同，并且是氢、低级烷基、芳基； R，是一至十个碳原子的烷基，其中包括支链、环状和不饱和烷基；一至六个碳原子的取代烷基，其中取代基为氨基、芳硫基、芳氧基、羟基、芳氨基和酰氨基；或烷基和杂烷基，可任选被卤代、低级烷基、羟基、氨基低级烷基、烷氧基和氨基取代，其中烷基含有一至六个碳原子； R2 是选自苯基、萘基或联苯基的芳基、取代芳基、杂芳基或取代杂芳基，其中取代基为羟基或低级烷氧基； X 是 CH2 或 S； 及其药学上可接受的盐类以及制备工艺。这些化合物是血管紧张素转换酶抑制剂，可用于治疗高血压。