(2S,3S,4S,5S,6R)-2-[3-[dimethyl-[3-[tris[3-[dimethyl-[3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]silyl]propyl]silyl]propyl]silyl]propoxy]-6-(hydroxymethyl)oxane-3,4,5-triol | 1228602-37-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S,3S,4S,5S,6R)-2-[3-[dimethyl-[3-[tris[3-[dimethyl-[3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]silyl]propyl]silyl]propyl]silyl]propoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 1228602-37-6
• 化学式: C₅₆H₁₁₆O₂₄Si₅
• 分子量: 1313.95
• InChiKey: VFVNLRJPVYMOST-VTOXIHFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.66
• 重原子数：
  85
• 可旋转键数：
  40
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  398
• 氢给体数：
  16
• 氢受体数：
  24

反应信息

• 作为产物：
  描述：

  在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 13.5h， 以56%的产率得到(2S,3S,4S,5S,6R)-2-[3-[dimethyl-[3-[tris[3-[dimethyl-[3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl]silyl]propyl]silyl]propyl]silyl]propoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
  参考文献：
  名称：

  Globular carbosilane dendrimers with mannose groups at the periphery: synthesis, characterization and toxicity in dendritic cells

  摘要：

  A synthetic strategy has been developed for the preparation of new globular carbosilane dendrimers with mannose groups at the periphery. It consists of hydrosilylation reaction of allyl tetraacetylmannose with carbosilane dendrimers containing monohydrosilane end groups and the subsequent deacetylation reaction. Evaluation of dendrimer toxicities in dendritic cells by MTT assay were carried out, and evidence a good biocompatibility. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.02.097