4-(4-methoxyphenyl)butyl 1-(2-cyclohexyl-2-oxoacetyl)-2-piperidinecarboxylate | 252002-79-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(4-methoxyphenyl)butyl 1-(2-cyclohexyl-2-oxoacetyl)-2-piperidinecarboxylate
• 英文别名: 1-(2-Cyclohexyl-2-oxo-acetyl)-piperidine-2-carboxylic acid 4-(4-methoxy-phenyl)-butyl ester；4-(4-methoxyphenyl)butyl 1-(2-cyclohexyl-2-oxoacetyl)piperidine-2-carboxylate
• CAS: 252002-79-2
• 化学式: C₂₅H₃₅NO₅
• 分子量: 429.557
• InChiKey: JEIJIIJQXIVPHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF<br/>[FR] NOUVEAUX INHIBITEURS ALLOSTÉRIQUES DU PROTÉASOME ET MÉTHODES D'UTILISATION ASSOCIÉES
  申请人：UNIV TEXAS

  公开号：WO2014201405A1

  公开（公告）日：2014-12-18

  The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.

  本发明涉及一般的新型蛋白酶体活性的变构调节剂，其制备和使用方法，以及其制药组合物。具体地，揭示了含有1-氧代芳酰基和疏水性酯侧链的哌啶-2-羧酸衍生物作为蛋白酶体2S活性的变构抑制剂，以及作为治疗蛋白酶体相关疾病的治疗剂在一个受体中的应用。
• Allosteric inhibitors of proteasome and methods of use thereof
  申请人：THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US10167259B2

  公开（公告）日：2019-01-01

  The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.

  本发明一般涉及蛋白酶体活性的新型异位调节剂、制备和使用方法及其药物组合物。具体而言，本发明公开了含有 1-氧代-芳酰基和亲油酯侧链的哌啶-2-羧酸衍生物，作为蛋白酶体 2S 活性的异构抑制剂，以及用于治疗受试者蛋白酶体相关疾病的治疗剂。
• Pipecolic acid derivative hair growth compositions and uses
  申请人：GPI NIL Holdings, Inc.

  公开号：US20010036947A1

  公开（公告）日：2001-11-01

  This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pipecolic acid derivatives.

  本发明涉及使用哌啶醇酸衍生物治疗脱发和促进毛发生长的药物组合物和方法。
• INHIBITORS OF ROTAMASE ENZYME ACTIVITY
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP0777478B1

  公开（公告）日：2001-11-07
• NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS
  申请人：Alcon, Inc.

  公开号：EP1227859B1

  公开（公告）日：2006-08-09