| 140935-95-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 140935-95-1
• 化学式: C₁₆H₃₀CuN₄O₄
• 分子量: 405.985
• InChiKey: CRPZFNDOSCIQDD-UHFFFAOYSA-L

反应信息

• 作为反应物：
  描述：

  copper dichloride 、 在 caesium carbonate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Non-Cross-Bridged Tetraazamacrocyclic Chelator for Stable ⁶⁴Cu-Based Radiopharmaceuticals

  摘要：

  N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with Cu-64 ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator.

  DOI：

  10.1021/ml400142s
• 作为产物：
  描述：

  copper(II) perchlorate hexahydrate 、 1,8-N,N'-bis-(carboxymethyl)-4,11-N'',N'''-bis-(methyl)-1,4,8,11-tetraazacyclotetradecane 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以85%的产率得到
  参考文献：
  名称：

  Non-Cross-Bridged Tetraazamacrocyclic Chelator for Stable ⁶⁴Cu-Based Radiopharmaceuticals

  摘要：

  N-mono/dimethylated TE2A tetraazamacrocycles (MM-TE2A and DM-TE2A) were synthesized in high yields. Both Cu-MM/DM-TE2A complexes showed increased kinetic stability compared to that of Cu-TE2A, whereas Cu-DM-TE2A showed even higher in vitro stability than that of Cu-ECB-TE2A. MM-TE2A and DM-TE2A were quantitatively radiolabeled with Cu-64 ions and showed rapid clearance from the body to emerge as a potential efficient bifunctional chelator.

  DOI：

  10.1021/ml400142s