| 1050481-18-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• CAS: 1050481-18-9
• 化学式: C₂₂H₂₇N₅O₄S*ClH
• 分子量: 494.014
• InChiKey: NTMPTMLFTUHGHF-NTISSMGPSA-N

反应信息

• 作为产物：
  描述：

  在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成
  参考文献：
  名称：

  Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors

  摘要：

  Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that mediates the cellular response to DNA-damage. A novel class of 2-ureido thiophene carboxamide urea (TCU) Chk1 inhibitors is described. Inhibitors in this chemotype were optimized for cellular potency and selectivity over Cdk1. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.016