| 1029529-53-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• CAS: 1029529-53-0
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: FSRCMBDWYPEXCX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 在 sodium borohydride cyanide 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs

  摘要：

  Semi-synthetic water-soluble analogs were synthesized from nocathiacin I through the formation of a versatile intermediate nocathiacin amine 5, and subsequent transformation via reductive amination, acylation or urea formation. Several of the novel analogs displayed much improved aqueous solubility over 1, while retained antibacterial activity. Compound 15 and 16 from the amide series, demonstrated excellent in vitro and in vivo antibacterial activity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.065