(3-Chlorophenyl)-[3-methyl-4-(2-piperidin-1-ylethoxy)phenyl]methanone | 1150104-91-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Chlorophenyl)-[3-methyl-4-(2-piperidin-1-ylethoxy)phenyl]methanone
• CAS: 1150104-91-8
• 化学式: C₂₁H₂₄ClNO₂
• 分子量: 357.88
• InChiKey: NBDXFUWREPLKKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-chlorophenyl-(4-hydroxy-3-methylphenyl)methanone 、 1-(2-氯乙基)哌啶盐酸盐 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 9.0h， 生成 (3-Chlorophenyl)-[3-methyl-4-(2-piperidin-1-ylethoxy)phenyl]methanone
  参考文献：
  名称：

  Benzophenone-N-ethyl piperidine ether analogues—Synthesis and efficacy as anti-inflammatory agent

  摘要：

  A sequence of substituted benzophenone-N-ethyl piperidine ether analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-inflammatory and ulcerogenic activities of the compounds were compared with naproxen, indomethacin, and phenylbutazone. These analogues showed an interesting anti-inflammatory activity in carrageenan-induced foot pad edema assay. In the air-pouch test, some of the analogues reduced the total number of leukocytes of the exudate, which indicates inhibition of prostaglandin production. Side effects of the compounds were examined on gastric mucosa, in the liver and stomach. None of the compounds illustrated significant side effects compared with standard drugs like indomethacin and naproxen. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.070

文献信息

• Benzophenone-N-ethyl piperidine ether analogues—Synthesis and efficacy as anti-inflammatory agent
  作者：Shaukath A. Khanum、V. Girish、S.S. Suparshwa、Noor Fatima Khanum

  DOI：10.1016/j.bmcl.2009.02.070

  日期：2009.4

  A sequence of substituted benzophenone-N-ethyl piperidine ether analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-inflammatory and ulcerogenic activities of the compounds were compared with naproxen, indomethacin, and phenylbutazone. These analogues showed an interesting anti-inflammatory activity in carrageenan-induced foot pad edema assay. In the air-pouch test, some of the analogues reduced the total number of leukocytes of the exudate, which indicates inhibition of prostaglandin production. Side effects of the compounds were examined on gastric mucosa, in the liver and stomach. None of the compounds illustrated significant side effects compared with standard drugs like indomethacin and naproxen. (C) 2009 Elsevier Ltd. All rights reserved.