(κ2-O,O-kaempferol)(κ2-N,N-1,10-phenanthroline)zinc(II) chloride | 1482348-51-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: (κ2-O,O-kaempferol)(κ2-N,N-1,10-phenanthroline)zinc(II) chloride
• 英文别名: (κ²-O,O-kaempferol)(κ²-N,N-1,10-phenanthroline)zinc(II) chloride
• CAS: 1482348-51-5
• 化学式: C₂₇H₁₇N₂O₆Zn*Cl*H₂O
• 分子量: 584.3
• InChiKey: GMSIWRRZJUGFJB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 山奈酚 、 zinc(II) chloride 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以77%的产率得到(κ2-O,O-kaempferol)(κ2-N,N-1,10-phenanthroline)zinc(II) chloride
  参考文献：
  名称：

  Synthesis, characterization, DNA interaction, and antitumor activities of mixed-ligand metal complexes of kaempferol and 1,10-phenanthroline/2,2′-bipyridine

  摘要：

  Four novel mixed-ligand metal complexes with the composition [Cu(Kae)(phen)]Cl center dot 2H(2)O (1), [Cu(Kae)(bpy)]Cl center dot H2O (2), [Zn(Kae)(phen)]Cl center dot H2O (3), and [Zn(Kae)(bpy)]Cl center dot H2O (4), where Kae = kaempferol, phen = 1,10-phenanthroline, bpy = 2,2'-bipyridine were synthesized and characterized by elemental analysis, IR, UV, H-1 NMR, C-13 NMR, HRMS ,and molar conductivity. The binding and cleavage abilities of complexes 1-4 with DNA have been studied by fluorescence spectroscopy, viscosity measurements, and gel electrophoresis under physiological conditions. The experimental results indicated that four complexes could bind to CT-DNA via an intercalative mode, and the complex 1 showed the strongest activity to cleavage DNA (pUC 19). The in vitro cytotoxicities of kaempferol and complexes 1-4 were also evaluated against human breast carcinoma cells by MTT assays. The results show that the cytotoxicities of complexes 1-4 are much higher than that of kaempferol alone, and the complex 1 shows the strongest ability to inhibit the growth of human breast carcinoma cells. The results suggest that the complex 1 may be a valuable tool in cancer chemotherapy agents.

  DOI：

  10.1007/s00044-013-0863-2