5-phenyl-1H-pyrrole-3-carbohydrazide | 428439-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 5-phenyl-1H-pyrrole-3-carbohydrazide
• CAS: 428439-59-2
• 化学式: C₁₁H₁₁N₃O
• 分子量: 201.228
• InChiKey: AUKPYRKULOBMSV-UHFFFAOYSA-N

物化性质

• 密度：
  1.253±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.9
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,4-二氯苯甲醛 、 5-phenyl-1H-pyrrole-3-carbohydrazide 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以75%的产率得到(3',4'-dichlorobenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide
  参考文献：
  名称：

  Synthesis and analgesic-antiinflammatory activities of novel acylarylhydrazones with a 5-phenyl-4-R-3-pyrrolyl-acyl moiety

  摘要：

  A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated for their analgesic-antiinflammatory activities. All synthesized compounds showed a significant analgesic action in mice after intraperitoneal administration at a dose of 100 muM/kg. Two of these, 1b, (4'-methylbenzylidene)-5-phenyl-1H-pyrrole-3-carsar-, bohydrazide, and 1d, (4'-chlorobenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, were found to be more potent as antinociceptive agents respect to dipyrone and indometacin, used as reference drugs. Among compounds 1, only 1b showed a moderate antiinflammatory effect in rats while 1d proved to be a potent non antiinflam-. matory analgesic.

  DOI：

  10.1002/1521-4184(200112)334:12<393::aid-ardp393>3.0.co;2-p
• 作为产物：
  描述：

  5-苯基-1H-吡咯-3-羧酸乙酯 在 一水合肼 作用下， 反应 1.0h， 以91%的产率得到5-phenyl-1H-pyrrole-3-carbohydrazide
  参考文献：
  名称：

  Synthesis and analgesic-antiinflammatory activities of novel acylarylhydrazones with a 5-phenyl-4-R-3-pyrrolyl-acyl moiety

  摘要：

  A new series of arylidene 5-phenyl-4-R-pyrrole-3-carbohydrazides 1a-j were prepared and evaluated for their analgesic-antiinflammatory activities. All synthesized compounds showed a significant analgesic action in mice after intraperitoneal administration at a dose of 100 muM/kg. Two of these, 1b, (4'-methylbenzylidene)-5-phenyl-1H-pyrrole-3-carsar-, bohydrazide, and 1d, (4'-chlorobenzylidene)-5-phenyl-1H-pyrrole-3-carbohydrazide, were found to be more potent as antinociceptive agents respect to dipyrone and indometacin, used as reference drugs. Among compounds 1, only 1b showed a moderate antiinflammatory effect in rats while 1d proved to be a potent non antiinflam-. matory analgesic.

  DOI：

  10.1002/1521-4184(200112)334:12<393::aid-ardp393>3.0.co;2-p