4-[N-phenyl-N'-methylsulfonylamidino]morpholine | 1123883-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-[N-phenyl-N'-methylsulfonylamidino]morpholine
• 英文别名: N-(Methylsulfonyl)-Na(2)-phenyl-4-morpholinecarboximidamide；N'-methylsulfonyl-N-phenylmorpholine-4-carboximidamide
• CAS: 1123883-56-6
• 化学式: C₁₂H₁₇N₃O₃S
• 分子量: 283.351
• InChiKey: XOAZDRLNSCOPLM-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  吗啉 、 N-methanesulfonylbenzamidine 在 4-碘化甲苯二乙酸酯 、 三乙胺 作用下， 以 乙二醇二甲醚 为溶剂， 反应 4.0h， 以43%的产率得到4-[N-phenyl-N'-methylsulfonylamidino]morpholine
  参考文献：
  名称：

  N-Perfluoroalkylsulfonylimido derivatives of arenecarboxylic acid amides and their oxidative aza Hofmann rearrangement

  摘要：

  The analogues of carboxamides in which the sp(2)-hybridized oxygen atom is replaced by more electron-withdrawing groups, =NSO(2)CF(3) and =NSO(2)C(4)F(9), have been synthesized. The resulting N-perfluoroalkylsulfonyl arenecarboxamidines ArC(=NSO(2)R(f))NH(2) (Rf = CF(3), C(4)F(9)) undergo an oxidative Hofmann-type rearrangement to the corresponding carbodiimides ArN=C=NSO(2)R(f) under the action of (diacyloxy-iodo)arenes. Rearrangement of related compounds ArC(=NSO(2)R)NH(2) (R = CH(3), Ph) containing fluorine-free substituents at the sulfonyl group also occurs in similar conditions. It was found that the reactivity of amidines rises with the increasing electron-withdrawing ability of the substituent R. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2008.03.001