7-methoxy-5-(morpholin-4-ylmethyl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione | 916574-82-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-methoxy-5-(morpholin-4-ylmethyl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
• 英文别名: 14-Methoxy-9-(morpholin-4-ylmethyl)-9,19-diazapentacyclo[10.7.0.02,6.07,11.013,18]nonadeca-1(12),2(6),7(11),13(18),14,16-hexaene-8,10-dione
• CAS: 916574-82-8
• 化学式: C₂₃H₂₃N₃O₄
• 分子量: 405.453
• InChiKey: LZIOTMNIDKHSTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吗啉 、 聚合甲醛 、 11-methoxy-4,5,6,7-tetrahydro-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione 以 乙醇 为溶剂， 反应 5.0h， 生成 7-methoxy-5-(morpholin-4-ylmethyl)-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione
  参考文献：
  名称：

  WO2008/63644

  摘要：

  公开号：

文献信息

• NOVEL MULTICYCLIC COMPOUNDS AND THE USE THEREOF
  申请人：Chatterjee Sankar

  公开号：US20110059959A1

  公开（公告）日：2011-03-10

  The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

  本发明涉及新型多环分子，可介导酶活性。特别是，这些化合物可以在治疗与PARP、VEGFR2和MLK3酶活性相关的疾病或疾病状态方面发挥作用，包括例如神经退行性疾病、炎症、缺血和癌症。
• CYCLOALKANOPYROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS
  申请人：CEPHALON, INC.

  公开号：EP2066324B1

  公开（公告）日：2013-05-29
• METHOD OF RADIO-SENSITIZING TUMORS USING A RADIO-SENSITIZING AGENT
  申请人：Cephalon, Inc.

  公开号：EP2086525B1

  公开（公告）日：2010-10-06
• Method of radio-sensitizing tumors using a radio-sensitizing agent
  申请人：Diebold James L.

  公开号：US20080146556A1

  公开（公告）日：2008-06-19

  The present invention relates to a method of treating cancer using PARP inhibitors as radio-sensitization agents of tumors. Specifically the present invention relates to a method of radio-sensitization of tumors using a compound of Formula (I) or a pharmaceutically acceptable salt form thereof. The present invention also relates to a pharmaceutical compositions of PARP inhibitors for radiosensitizing tumors.
• [EN] NOVEL MULTICYCLIC COMPOUNDS AND THE USE THEREOF<br/>[FR] NOUVEAUX COMPOSÉS MULTICYCLIQUES ET LEUR UTILISATION
  申请人：CEPHALON INC

  公开号：WO2007149451A2

  公开（公告）日：2007-12-27

  (EN) The present invention is directed to novel multicyclic molecules of Formula (IIIIa)* that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP3 VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.(FR) La présente invention porte sur de nouvelles molécules multicycliques qui assurent la médiation d'une activité enzymatique. En particulier, les composés peuvent être efficaces dans le traitement de maladies ou d'états liés à des maladies se rapportant à l'activité de PARP, VEGFR2, et des enzymes MLK3, notamment, les maladies neurodégénératives, l'inflammation, l'ischémie et le cancer.